Altered cytokine expression in Helicobacter pylori infected patients with bleeding duodenal ulcer
2019
Аутори:
Milić, LjiljanaKaramarković, Aleksandar
Popadić, Dušan
Šijački, Ana
Grigorov, Ilijana
Milošević, Emina
Ćuk, Vladica
Pesko, Predrag
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Objective
Peptic ulcer disease is a condition in which an important role has infection with H. pylori. The most common complication of peptic ulcer is bleeding. The presence of H. pylori triggers local and systemic cytokine signaling which may affect processes such as healing, gastric or duodenal rupture, and carcinogenesis. In this study, we examined the concentrations of IL-1β, IL-6, IL-10, TNF, TGF-β and IL-17A in serum by enzyme immunoassay and their mRNA expressions in periulcer biopsies obtained from patients with bleeding peptic ulcer by means of real-time-PCR.
Results
We have shown that pro-inflammatory IL-6 and TNF concentrations in serum were significantly higher in patients who were infected with H. pylori, while the concentrations of TGF-β and IL-17A were significantly lower compared to non-infected subjects. IL-17A expression in periulcer mucosa was significantly higher in patients who were infected with H. pylori, while the expression of other cytokines, there was no significant difference compared to non-infected controls. Considering higher serum concentrations in non-infected subjects and higher IL-17A expression in mucosal tissue of infected patients, our data support the studies that found IL-17A has protective role in eradication of H. pylori infection in infected patients.
Кључне речи:
Bleeding ulcer; Proinflammatory cytokines; Helicobacter pylori; Real-time-PCRИзвор:
BMC Research Notes, 2019, 12, 278-Финансирање / пројекти:
- Имунопатогенетски и регулаторни механизми у аутоимунским болестима и хроничној инфламацији (RS-MESTD-Basic Research (BR or ON)-175038)
URI
https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-019-4310-4https://radar.ibiss.bg.ac.rs/handle/123456789/3362