Приказ основних података о документу
The role of macrophage migration inhibitory factor in obesity-associated type 2 diabetes in mice
dc.creator | Saksida, Tamara | |
dc.creator | Stošić-Grujičić, Stanislava | |
dc.creator | Stojanović, Ivana D. | |
dc.date.accessioned | 2015-08-28T10:26:51Z | |
dc.date.available | 2015-08-28T10:26:51Z | |
dc.date.issued | 2013 | |
dc.date.issued | 2013 | sr |
dc.identifier.issn | 0354-4664 | sr |
dc.identifier.other | Rad_konverzija_392 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/336 | |
dc.description.abstract | Macrophage migration inhibitory factor (MIF) is implicated in the pathogenesis of several inflammationrelated diseases, including obesity and type 2 diabetes (T2D). However, MIF deficiency itself promotes obesity and glucose intolerance in mice. Here we show that the introduction of a high-fat diet (HFD) further aggravates the parameters of obesity-associated T2D: weight gain and glucose intolerance. Furthermore, in contrast to MIF-KO mice on standard chow, HFD-fed MIF-KO mice develop insulin resistance. Although the clinical signs of obesity-associated T2D are upgraded, inflammation in MIF-deficient mice on HFD is significantly lower. These results imply that MIF possesses a complex role in glucose metabolism and the development of obesity-related T2D. However, the downregulation of inflammation upon MIF inhibition could be a useful tool in short-term T2D therapy for preventing pancreatic islet deterioration. | en |
dc.description.sponsorship | Projekat ministarstva br. 173013 | sr |
dc.language.iso | eng | sr |
dc.rights | openAccess | sr |
dc.source | Archives of Biological Sciences | sr |
dc.subject | macrophage migration inhibitory factor | ENG |
dc.subject | type 2 diabetes | ENG |
dc.subject | obesity | ENG |
dc.subject | inflammation | ENG |
dc.title | The role of macrophage migration inhibitory factor in obesity-associated type 2 diabetes in mice | en |
dc.type | article | sr |
dc.rights.license | ARR | |
dcterms.abstract | Стошић-Грујичић, Станислава Д.; Саксида, Тамара; Стојановић, Ивана; | |
dc.citation.issue | 2 | sr |
dc.citation.volume | 65 | sr |
dc.citation.spage | 499 | sr |
dc.citation.epage | 505 | sr |
dc.type.version | publishedVersion | sr |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs//bitstream/id/2470/Rad_konverzija_392.pdf | |
dc.citation.rank | M23 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_336 |