Strain differences in toxicity of oral cadmium intake in rats
2016
Аутори:
Ninkov, MarinaPopov Aleksandrov, Aleksandra
Mirkov, Ivana
Demenesku, Jelena
Tucović, Dina
Jovanović Stojanov, Sofija
Golic, Natasa
Tolinacki, Maja
Kataranovski, Dragan
Brceski, Ilija
Kataranovski, Milena
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2016 Elsevier Ltd.
Метаподаци
Приказ свих података о документуАпстракт:
Influence of genetic background on toxicity of oral cadmium (Cd) administration (30 days, in drinking
water; 5 ppm and 50 ppm of cadmium) was examined in Albino Oxford (AO) and Dark Agouti (DA) rats.
Similar cadmium deposition was noted in gut and draining mesenteric lymph nodes (MLN) of both
strains but intensity and/or the pattern of responses to cadmium in these tissues differ. Less intense
intestinal damage and leukocyte infiltration was observed in gut of cadmium-exposed AO rats. While
gut-associated lymph node cells of DA rats responded to cadmium with an increase of cell proliferation,
oxidative activity, IFN-g, IL-17 production and expression, no changes of these activities of MLN cells of
cadmium-treated AO rats were observed. Spleen, which accumulated cadmium comparable to MLN,
responded to metal by drop in cell viability and by reduced responsiveness of proliferation and cytokine
production to stimulation in DA rats solely, which suggest tissue dependence of cadmium effects. More
pronounced cadmium effects on MLN and spleen cells of DA rats (which accumulated similar cadmium
doses as AO rats), showed greater susceptibility of this strain to cadmium. The results presented, for the
first time, depict the influence of genetic background to effects of oral cadmium administration.
Кључне речи:
Oral cadmium administration; AO and DA rats; Spleen; Intestine; Mesenteric lymph nodesИзвор:
Food and Chemical Toxicology, 2016, 96, 11-23Финансирање / пројекти:
- Имуномодулаторни ефекти ксенобиотика и биотичких фактора животне средине на популације мишоликих глодара (RS-173039)
DOI: 10.1016/j.fct.2016.07.021
PubMed: 27451944
WoS: 000383825300002
Scopus: 2-s2.0-84979701170
URI
https://www.sciencedirect.com/science/article/pii/S0278691516302423?via%3Dihubhttps://radar.ibiss.bg.ac.rs/handle/123456789/3378