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Strain differences in toxicity of oral cadmium intake in rats
dc.creator | Ninkov, Marina | |
dc.creator | Popov Aleksandrov, Aleksandra | |
dc.creator | Mirkov, Ivana | |
dc.creator | Demenesku, Jelena | |
dc.creator | Tucović, Dina | |
dc.creator | Jovanović Stojanov, Sofija | |
dc.creator | Golic, Natasa | |
dc.creator | Tolinacki, Maja | |
dc.creator | Kataranovski, Dragan | |
dc.creator | Brceski, Ilija | |
dc.creator | Kataranovski, Milena | |
dc.date.accessioned | 2019-07-03T13:01:25Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2016 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0278691516302423?via%3Dihub | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3378 | |
dc.description.abstract | Influence of genetic background on toxicity of oral cadmium (Cd) administration (30 days, in drinking water; 5 ppm and 50 ppm of cadmium) was examined in Albino Oxford (AO) and Dark Agouti (DA) rats. Similar cadmium deposition was noted in gut and draining mesenteric lymph nodes (MLN) of both strains but intensity and/or the pattern of responses to cadmium in these tissues differ. Less intense intestinal damage and leukocyte infiltration was observed in gut of cadmium-exposed AO rats. While gut-associated lymph node cells of DA rats responded to cadmium with an increase of cell proliferation, oxidative activity, IFN-g, IL-17 production and expression, no changes of these activities of MLN cells of cadmium-treated AO rats were observed. Spleen, which accumulated cadmium comparable to MLN, responded to metal by drop in cell viability and by reduced responsiveness of proliferation and cytokine production to stimulation in DA rats solely, which suggest tissue dependence of cadmium effects. More pronounced cadmium effects on MLN and spleen cells of DA rats (which accumulated similar cadmium doses as AO rats), showed greater susceptibility of this strain to cadmium. The results presented, for the first time, depict the influence of genetic background to effects of oral cadmium administration. | en |
dc.language.iso | en | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173039/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Food and Chemical Toxicology | sr |
dc.subject | Oral cadmium administration | sr |
dc.subject | AO and DA rats | sr |
dc.subject | Spleen | sr |
dc.subject | Intestine | sr |
dc.subject | Mesenteric lymph nodes | sr |
dc.title | Strain differences in toxicity of oral cadmium intake in rats | en |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Катарановски, Милена; Деменеску, Јелена; Попов Aлександров, Aлександра; Голиц, Натаса; Катарановски, Драган; Туцовић, Дина; Јовановић Стојанов, Софија; Нинков, Марина; Мирков, Ивана; Толинацки, Маја; Брцески, Илија; | |
dc.rights.holder | © 2016 Elsevier Ltd. | sr |
dc.citation.volume | 96 | |
dc.identifier.doi | 10.1016/j.fct.2016.07.021 | |
dc.identifier.pmid | 27451944 | |
dc.identifier.scopus | 2-s2.0-84979701170 | |
dc.identifier.wos | 000383825300002 | |
dc.citation.apa | Ninkov, M., Popov Aleksandrov, A., Mirkov, I., Demenesku, J., Mileusnic, D., Jovanovic Stojanov, S., et al. (2016). Strain differences in toxicity of oral cadmium intake in rats. Food and Chemical Toxicology, 96, 11–23. | |
dc.citation.vancouver | Ninkov M, Popov Aleksandrov A, Mirkov I, Demenesku J, Mileusnic D, Jovanovic Stojanov S, Golic N, Tolinacki M, Zolotarevski L, Kataranovski D, Brceski I, Kataranovski M. Strain differences in toxicity of oral cadmium intake in rats. Food Chem Toxicol. 2016;96:11–23 | |
dc.citation.spage | 11 | |
dc.citation.epage | 23 | |
dc.type.version | publishedVersion | sr |
dc.citation.rank | aM21 |