Reactive oxygen, nitrogen, and sulfur species in human male fertility. A crossroad of cellular signaling and pathology.
2020
Document Type:
Article (Published version)
,
© 2019 International Union of Biochemistry and Molecular Biology
Metadata
Show full item recordAbstract:
Infertility is a significant global health problem that currently affects one of six couples in reproductive age. The quality of male reproductive cells dramatically decreased over the last years and almost every aspect of modern life additionally worsen sperm functional parameters that consequently markedly increase male infertility. This clearly points out the importance of finding a new approach to treat male infertility. Redox signaling mediated by reactive oxygen, nitrogen and sulfur species (ROS, RNS, and RSS respectively), has appeared important for sperm reproductive function. Present review summarizes the current knowledge of ROS, RNS, and RSS in male reproductive biology and identifies potential targets for development of novel pharmacological and therapeutic approaches for male infertility by targeted therapeutic modulation of redox signaling.
Keywords:
Infertility; Reactive nitrogen species; Reactive oxygen species; Reactive sulfur species; SpermatozoaSource:
BioFactors (Oxford, England), 2020, 46, 2, 206-219Funding / projects:
- Reactive oxygen and nitrogen species functions in reproduction: possible pharmacological tools to treat human infertility (RS-MESTD-Basic Research (BR or ON)-173054)
DOI: 10.1002/biof.1535
ISSN: 0951-6433
PubMed: 31185138
WoS: 000524885800003
Scopus: 2-s2.0-85067381921
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/biof.1535https://radar.ibiss.bg.ac.rs/handle/123456789/3385