Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss.
2019
Аутори:
Nikolakopoulou, Angeliki M.Montagne, Axel
Kisler, Kassandra
Dai, Zhonghua
Wang, Yaoming
Huuskonen, Mikko T.
Sagare, Abhay P.
Lazić, Divna
Sweeney, Melanie D.
Kong, Pan
Wang, Min
Owens, Nelly Chuqui
Lawson, Erica J.
Xie, Xiaochun
Zhao, Zhen
Zloković, Berislav V.
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.
Метаподаци
Приказ свих података о документуАпстракт:
Pericytes are positioned between brain capillary endothelial cells, astrocytes and neurons. They degenerate in multiple neurological disorders. However, their role in the pathogenesis of these disorders remains debatable. Here we generate an inducible pericyte-specific Cre line and cross pericyte-specific Cre mice with iDTR mice carrying Cre-dependent human diphtheria toxin receptor. After pericyte ablation with diphtheria toxin, mice showed acute blood-brain barrier breakdown, severe loss of blood flow, and a rapid neuron loss that was associated with loss of pericyte-derived pleiotrophin (PTN), a neurotrophic growth factor. Intracerebroventricular PTN infusions prevented neuron loss in pericyte-ablated mice despite persistent circulatory changes. Silencing of pericyte-derived Ptn rendered neurons vulnerable to ischemic and excitotoxic injury. Our data demonstrate a rapid neurodegeneration cascade that links pericyte loss to acute circulatory collapse and loss of PTN neurotrophic support. These findings may have implications for the pathogenesis and treatment of neurological disorders that are associated with pericyte loss and/or neurovascular dysfunction.
Извор:
Nature Neuroscience, 2019, 22, 7, 1089-1098Финансирање / пројекти:
- National Institutes of Health: R01NS090904,R01NS034467,R01AG039452,R01NS100459,R01AG023084
DOI: 10.1038/s41593-019-0434-z
PubMed: 31235908
WoS: 000472612100010
Scopus: 2-s2.0-85067868288
URI
http://www.nature.com/articles/s41593-019-0434-zhttps://radar.ibiss.bg.ac.rs/handle/123456789/3388