Effects of ibogaine per os treatment on redox homeostasis in rat kidney
2019
Аутори:
Vidonja Uzelac, TeodoraTatalović, Nikola
Mijović, Milica
Nikolić-Kokić, Aleksandra
Oreščanin Dušić, Zorana
Bresjanac, Mara
Blagojević, Duško
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Our previous results showed that a single oral dose (1 or 20 mg/kg body weight) of the anti-addiction agent ibogaine induced in rats 6 and 24 h after administration glycogenolytic activity in hepatocytes, followed by a mild oxidative stress. In this work, we examined the in vivo effect of the same doses of ibogaine on rat kidney morphology, antioxidant enzyme (superoxide dismutases (SOD1 and 2), catalase, glutathione peroxidase, glutathione reductase (GR) and glutathione- S-transferase) activities, and oxidative stress (TBARS) and redox (-SH groups) parameters. The dose of 1 mg/kg ibogaine induced an elevation in SOD1 activity and decreased GR activity after 6 and 24 h. GR activity was decreased at 6 and 24 h after 20 mg/kg ibogaine administration, suggesting changed redox homeostasis. After 24 h, we observed an increase in moderate morphological changes, without changes in urinalyses, indicating that kidney function was not measurably affected. Nevertheless, kidney-function monitoring during and following ibogaine use in human subjects is advisable.
Кључне речи:
ibogaine; Kidney; Antioxidant enzymes; Lipid peroxidation; Proximal tubulesИзвор:
Archives of Biological Sciences, 2019, 71, 2, 245-252Финансирање / пројекти:
- Молекуларни механизми редокс сигналинга у хомеостази, адаптацији и патологији (RS-MESTD-Basic Research (BR or ON)-173014)
- ARRS (P3-0171)
DOI: 10.2298/ABS190208006V
ISSN: 0354-4664
WoS: 000471069700006
Scopus: 2-s2.0-85067113922
URI
http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641900006Vhttp://www.serbiosoc.org.rs/arch/index.php/abs/article/view/3984
https://radar.ibiss.bg.ac.rs/handle/123456789/3395