Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa.
2019
Autori:
Stanković, JovanaGođevac, Dejan
Tešević, Vele
Dajić-Stevanović, Zora
Ćirić, Ana
Soković, Marina
Novaković, Miroslav
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2019 American Chemical Society and American Society of Pharmacognosy.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
A new flavonoid glucoside derivative, patuletin 3 -O-(2- O-feruloyl)-β-d-glucuronopyranosyl-(1→2)-β-d-glucopyranoside, named atriplexin IV (1), and three new triterpenoid saponin derivatives, two sulfonylated, β-d-glucopyranosyl-3 -O-(2- O-sulfo-β-d-galactopyranosyl)-(1→2)-α-l-arabinopyranoside-30-alolean-12-en-28-oate (2), named atriplexogenin I, β-d-glucopyranosyl-3- O-(2- O-sulfo-β-d-galactopyranosyl)-(1→2)-α-l-arabinopyranoside)-30-hydroxyolean-12-en-28-oate (3), named atriplexogenin II, and β-d-glucopyranosyl-3 -O-(β-d-glucopyranosyl-(1→2)-β-d-galactopyranosyl-(1→2)-α-l-arabinopyranoside)-30-alolean-12-en-28-oate (4), named atriplexogenin III, were isolated by silica gel column and semipreparative HPLC chromatography from the n-butanol extract of the salt marsh plant Atriplex tatarica. In addition, two known secondary metabolites, patuletin3 -O-β-d-apiofuranosyl-(1‴→2″)-β-d-glucopyranoside (5) and patuletin 3 -O-5‴- O-feruloyl-β-d-apiofuranosyl-(1‴→2″)-β-d-glucopyranoside (6), were isolated for the first time from A. tatarica. The structures of the isolated compounds were elucidated by 1D and 2D NMR, HRESIMS, IR, and UV data. Antibacterial activity by the microdilution method and antibiofilm activity against P. aeruginosa were assessed. Compound 5 possesses significant antibacterial activity, while the most potent antibiofilm agent is compound 2.
Ključne reči:
m21Izvor:
Journal of Natural Products, 2019, 82, 6, 1487-1495Finansiranje / projekti:
- Bioaktivni prirodni proizvodi samoniklih, gajenih i jestivih biljaka: određivanje struktura i aktivnosti (RS-MESTD-Basic Research (BR or ON)-172053)
- Karakterizacija i primena metabolita gljiva i utvrđivanje potencijala novih biofungicida (RS-MESTD-Basic Research (BR or ON)-173032)
- Morfološka, hemijska, farmakološka i agronomska karakterizacija panonskog timijana (Thymus pannonicus All., Lamiaceae), sa ciljem njegove održive proizvodnje u intenzivnom sistemu ratarenja (RS-MESTD-Technological Development (TD or TR)-31089)
DOI: 10.1021/acs.jnatprod.8b00970
PubMed: 31181926
WoS: 000473827300011
Scopus: 2-s2.0-85067065776
URI
http://pubs.acs.org/doi/10.1021/acs.jnatprod.8b00970https://radar.ibiss.bg.ac.rs/handle/123456789/3397