New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunium species
2019
Аутори:
Zengin, GokhanPaksoy, Mehmet Yavuz
Aumeeruddy, Muhammad Zakariyyah
Glamočlija, Jasmina
Soković, Marina
Diuzheva, Alina
Jekő, József
Cziáky, Zoltán
Rodrigues, Maria João
Custodio, Luisa
Mahomoodally, Mohamad Fawzi
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2019 Elsevier Ltd.
Метаподаци
Приказ свих података о документуАпстракт:
Bunium species have been reported to be used both as food and in traditional medicines. The scientific community has attempted to probe into the pharmacological and chemical profiles of this genus. Nonetheless, many species have not been investigated fully to date. In this study, we determined the phenolic components, antimicrobial, antioxidant, and enzyme inhibitory activities of aerial parts of four Bunium species (B. sayai, B. pinnatifolium, B. brachyactis and B. macrocarpum). Results showed that B. microcarpum and B. pinnatifolium were strong antioxidants as evidenced in the DPPH, ABTS, CUPRAC, and FRAP assays. B. brachyactis was the most effective metal chelator, and displayed high enzyme inhibition against cholinesterase, tyrosinase, amylase, glucosidase, and lipase. The four species showed varied antimicrobial activity against each microorganism. Overall, they showed high activity against P. mirabilis and E. coli (MIC and MBC <1 mg mL−1). B. brachyactis was more effective against Aspergillus versicolor compared to the standard drug ketoconazole. B. brachyactis was also more effective than both ketoconazole and bifonazole against Trichoderma viride. B. sayai was more effective than ketoconazole in inhibiting A. fumigatus. B. sayai was most non-toxic to HEK 293 (cellular viability = 117%) and HepG2 (cellular viability = 104%). The highest level of TPC was observed in B. pinnatifolium (35.94 mg GAE g−1) while B. microcarpum possessed the highest TFC (39.21 mg RE g−1). Seventy four compounds were detected in B. microcarpum, 70 in B. brachyactis, 66 in B. sayai, and 51 in B. pinnatifolium. Quinic acid, chlorogenic acid, pantothenic acid, esculin, isoquercitrin, rutin, apigenin, and scopoletin were present in all the four species. This study showed that the four Bunium species are good sources of biologically active compounds with pharmaceutical and nutraceutical potential.
Кључне речи:
Bunium; Phytoconstituents; Cytotoxicity; Antioxidant; Enzyme inhibitorsИзвор:
Food Research International, 2019, 123, 414-424
DOI: 10.1016/J.FOODRES.2019.05.013
WoS: 000477091700044
Scopus: 2-s2.0-85065659864
URI
https://www.sciencedirect.com/science/article/pii/S0963996919303163?via%3Dihubhttps://radar.ibiss.bg.ac.rs/handle/123456789/3407