Citrus flavanones naringenin and hesperetin induced mild functional alteration in thyroids of old-aged Wistar rats
2017
Аутори:
Miler, MarkoAjdžanović, Vladimir
Ristić, Nataša
Filipović, Branko
Ušćebrka, Gordana
Miljić, Dragana
Milošević, Verica
Šošić-Jurjević, Branka
Тип документа:
Конференцијски прилог (Објављена верзија)
,
© Bioscientifica Ltd.
Метаподаци
Приказ свих података о документуАпстракт:
Aging is a complex process characterized by a progressive decline in cellular
function, alterations of the endocrine system and the increased incidence of
thyroid diseases. Citrus flavanones naringenin (NAR) and hesperetin (HES) may
contribute to maintenance of health at old age however they may also affect
thyroid hormone economy. The aim of this study was to test weather NAR or HES
administration alter thyroid functioning. NAR or HES were administrated orally
(15 mg/kg) to male 24-month-old Wistar rats during 4 weeks. Control groups
received vehicle, sunflower oil. Immunohistochemical staining of thyroglobulin
(Tg), thyroxine (T4) bound to Tg (T4-Tg) and sodium iodide sysmporter (NIS)
were performed. Immunopositivity of Tg or T4-Tg in thyroid follicles were
measured as intensity of optical density (OD) or relative intensity of fluorescence
(RIF). Thyroid stimulating hormone (TSH) and total T4 concentrations were
measured in serum. After citrus flavanones treatments, thyroids showed Tg and
T4-Tg immunopositivity mainly in the colloid of the follicles. The obtained
results showed increased (P ! 0.05) intensity of OD for Tg and T4-Tg RIF after
both flavanones treatments, while NIS expression did not change. Serum TSH
increased (P ! 0.05) only after NAR, although T4 remained unchanged after both
treatments. In conclusion, citrus flavanones induced stronger expression of
thyroid-specific proteins in gland of old-aged males. However, only NAR
elevated serum TSH, being more potent than HES. This alteration is in line with
preserved capacity of the thyroid to compensate the mild interference of
flavanones treatments with thyroid hormone production in old-aged males.
Извор:
19th European Congress of Endocrinology; 2017 May 20-23; Lisbon, Portugal (Endocrine Abstracts; Vol. 49), 2017, GP202-Финансирање / пројекти:
- Одговор неуроендокриног система пацова на одабране биљне екстракте, фитоестрогене, стероидне и пептидне хормоне (RS-MESTD-Basic Research (BR or ON)-173009)