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Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration
dc.creator | Živanović, Jasmina | |
dc.creator | Kouroussis, Emilia | |
dc.creator | Kohl, Joshua B. | |
dc.creator | Adhikari, Bikash | |
dc.creator | Bursać, Biljana | |
dc.creator | Schott-Roux, Sonia | |
dc.creator | Petrović, Dunja | |
dc.creator | Miljković, Jan Lj. | |
dc.creator | Thomas-Lopez, Daniel | |
dc.creator | Jung, Youngeun | |
dc.creator | Miler, Marko | |
dc.creator | Mitchell, Sarah | |
dc.creator | Milošević, Verica | |
dc.creator | Gomes, Jose Eduardo | |
dc.creator | Benhar, Moran | |
dc.creator | Gonzales-Zorn, Bruno | |
dc.creator | Ivanović-Burmazović, Ivana | |
dc.creator | Torregrossa, Roberta | |
dc.creator | Mitchell, James R. | |
dc.creator | Whiteman, Matthew | |
dc.creator | Schwarz, Guenter | |
dc.creator | Snyder, Solomon H. | |
dc.creator | Paul, Bindu D. | |
dc.creator | Carroll, Kate S. | |
dc.creator | Filipović, Miloš R. | |
dc.date.accessioned | 2019-11-15T09:08:17Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1550-4131 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S1550413119305625 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3518 | |
dc.description.abstract | Life on Earth emerged in a hydrogen sulfide (H2S)-rich environment eons ago and with it protein persulfidation mediated by H2S evolved as a signaling mechanism. Protein persulfidation (S-sulfhydration) is a post-translational modification of reactive cysteine residues, which modulate protein structure and/or function. Persulfides are difficult to label and study due to their reactivity and similarity with cysteine. Here, we report a facile strategy for chemoselective persulfide bioconjugation using dimedone-based probes, to achieve highly selective, rapid, and robust persulfide labeling in biological samples with broad utility. Using this method, we show persulfidation is an evolutionarily conserved modification and waves of persulfidation are employed by cells to resolve sulfenylation and prevent irreversible cysteine overoxidation preserving protein function. We report an age-associated decline in persulfidation that is conserved across evolutionary boundaries. Accordingly, dietary or pharmacological interventions to increase persulfidation associate with increased longevity and improved capacity to cope with stress stimuli. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173009/RS// | |
dc.rights | restrictedAccess | |
dc.source | Cell Metabolism | |
dc.subject | Hydrogen sulfide | |
dc.subject | Protein persulfidation | |
dc.subject | Hydrogen peroxide | |
dc.subject | Sulfenylation | |
dc.subject | Sulfinylation | |
dc.subject | Sulfonylation | |
dc.subject | Redox signaling | |
dc.subject | Aging | |
dc.subject | Calorie restriction | |
dc.title | Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Aдхикари, Бикасх; Бурсаћ, Биљана; Сцхотт-Роуx, Сониа; Филиповић, Милош Р.; Петровић, Дуња; Миљковић, Јан Љ.; Тхомас-Лопез, Даниел; Јунг, Yоунгеун; Митцхелл, Сарах; Гомес, Јосе Едуардо; Бенхар, Моран; Гонзалес-Зорн, Бруно; Торрегросса, Роберта; Митцхелл, Јамес Р.; Wхитеман, Маттхеw; Сцхwарз, Гуентер; Снyдер, Соломон Х.; Паул, Бинду Д.; Царролл, Кате С.; Милер, Марко; Милошевић, Верица; Ивановић-Бурмазовић, Ивана; Живановић, Јасмина; Коуроуссис, Емилиа; Кохл, Јосхуа Б.; | |
dc.rights.holder | Crown Copyright © 2019 Published by Elsevier Inc. | |
dc.citation.issue | 6 | |
dc.citation.volume | 30 | |
dc.identifier.doi | 10.1016/J.CMET.2019.10.007 | |
dc.identifier.pmid | 31735592 | |
dc.identifier.scopus | 2-s2.0-85075485979 | |
dc.identifier.wos | 000500800300015 | |
dc.citation.apa | Zivanovic, J., Kouroussis, E., Kohl, J. B., Adhikari, B., Bursac, B., Schott-Roux, S., et al. (2019). Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration. Cell Metabolism, 30, 6, 1152-1170.e13 | |
dc.citation.vancouver | Zivanovic J, Kouroussis E, Kohl JB, Adhikari B, Bursac B, Schott-Roux S, Petrovic D, Miljkovic JL, Thomas-Lopez D, Jung Y, Miler M, Mitchell S, Milosevic V, Gomes JE, Benhar M, Gonzales-Zorn B, Ivanovic-Burmazovic I, Torregrossa R, Mitchell JR, Whiteman M, Schwarz G, Snyder SH, Paul BD, Carroll KS, Filipovic MR. Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration. Cell Metab. 2019;30(6):1152-1170.e13. | |
dc.citation.spage | 1152 | |
dc.citation.epage | 1170.e13 | |
dc.type.version | publishedVersion | |
dc.citation.rank | aM21 |