Quinoline-Conjugated Ruthenacarboranes: Toward Hybrid Drugs with a Dual Mode of Action.
2019
Preuzimanje 🢃
Autori:
Gozzi, MartaMurganic, Blagoje
Drača, Dijana
Popp, John
Coburger, Peter
Maksimović-Ivanić, Danijela
Mijatović, Sanja
Hey-Hawkins, Evamarie
Tip dokumenta:
Članak u časopisu (Recenzirana verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
The role of autophagy in cancer is often complex, ranging from tumor-promoting to -suppressing effects. In this study, two novel hybrid molecules were designed, containing a ruthenacarborane fragment conjugated with a known modulator of autophagy, namely a quinoline derivative. The complex closo-[3-(η6 -p-cymene)-1-(quinolin-8-yl-acetate)-3,1,2-RuC2 B9 H10 ] (4) showed a dual mode of action against the LN229 (human glioblastoma) cell line, where it inhibited tumor-promoting autophagy, and strongly inhibited cell proliferation, de facto blocking cellular division. These results, together with the tendency to spontaneously form nanoparticles in aqueous solution, make complex 4 a very promising drug candidate for further studies in vivo, for the treatment of autophagy-prone glioblastomas.
Ključne reči:
Autophagy; Glioblastoma; Quinoline; Ruthenacarborane; Self-assemblyIzvor:
ChemMedChem, 2019Finansiranje / projekti:
- Molekularni mehanizmi fiziološke i farmakološke kontrole inflamacije i kancera (RS-MESTD-Basic Research (BR or ON)-173013)
- Saxon State Ministry for Sciences and the Arts. Grant Number: LAU-R-N-11-2-0615
DOI: 10.1002/cmdc.201900349
PubMed: 31675152
WoS: 000497336700001
Scopus: 2-s2.0-85075377850
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201900349https://radar.ibiss.bg.ac.rs/handle/123456789/3534