Oral warfarin intake affects skin inflammatory cytokine responses in rats.
2017
Аутори:
Popov Aleksandrov, AleksandraMirkov, Ivana
Zolotarevski, Lidija
Ninkov, Marina
Tucović, Dina
Kataranovski, Dragan
Kataranovski, Milena
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2017 Elsevier B.V.
Метаподаци
Приказ свих података о документуАпстракт:
Warfarin is an anticoagulant used in prevention/prophylaxis of thromboembolism. Besides the effects on coagulation, non-hemorrhagic reactions have also been documented. Although cutaneous reactions were reported in some patients, the impact on skin immunity was not explored. In the present paper, the effect of 30-day oral warfarin intake on skin cytokine responses in rats was analyzed. Increased release of inflammatory cytokines (TNF, IL-1β and IL-10) was noted by skin explants from rats which received warfarin, but without effect on IL-6. No impact on epidermal cell cytokine secretion was seen, except a tendency of an increase of IL-6 response to stimulation with microbial product lipopolysaccharide (LPS). Topical application of contact allergen dinitrochlorobenzene (DNCB) resulted in slight (numerical solely) increase of TNF release by skin explants of warfarin-treated animals, while epidermal cells responded by increased secretion of all four cytokines examined. The data presented provide new information on the potential of oral warfarin to modulate skin innate immune activity.
Кључне речи:
Dinitrochlorobenzene; Epidermal cells; Inflammatory cytokines; Interleukin-10; Oral warfarin intake; Rats; SkinИзвор:
Environmental Toxicology and Pharmacology, 2017, 54, 93-98Финансирање / пројекти:
- Имуномодулаторни ефекти ксенобиотика и биотичких фактора животне средине на популације мишоликих глодара (RS-MESTD-Basic Research (BR or ON)-173039)
DOI: 10.1016/j.etap.2017.06.027
PubMed: 28704755
WoS: 000409288300013
Scopus: 2-s2.0-85021997872
URI
https://www.sciencedirect.com/science/article/pii/S1382668917301746?via%3Dihubhttps://radar.ibiss.bg.ac.rs/handle/123456789/3540