Blackstonia perfoliata (L.) Huds. (Gentianaceae): A promising source of useful bioactive compounds
2020
Аутори:
Mihailović, VladimirKatanić Stanković, Jelena S.
Jurić, Tatjana
Srećković, Nikola
Mišić, Danijela
Šiler, Branislav
Monti, Daria Maria
Imbimbo, Paola
Nikles, Stefanie
Pan, San-Po
Bauer, Rudolf
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2019 Elsevier B.V.
Метаподаци
Приказ свих података о документуАпстракт:
Blackstonia perfoliata (L.) Huds. is known as a highly bitter secoiridoid glycosides-containing plant and as a possible substitute for some Gentianaceae plants in herbal preparations. Nevertheless, its bioactive properties are still unknown. The present study aimed to characterize both, secoiridoid glycosides and phenolic constituents, and to investigate antioxidant, antimicrobial, anti-inflammatory, and cytotoxic activities of B. perfoliata methanolic extract. The secoiridoid glycosides swertiamarin, gentiopicrin, and sweroside were found to be the dominant compounds of the extract, while 23 phenolic compounds were identified in much lower concentrations. Among phenolics, flavanols were the most abundant, which represents a unique feature among Gentianaceae species. The extract showed moderate to weak antioxidant activity with better performance in inhibition of lipid peroxidation than in free radical scavenging activities. The extract showed generally better antifungal properties compared with its antibacterial potential. Also, B. perfoliata demonstrated in vitro anti-inflammatory activity, the extract (50 μg/mL) showed inhibition of cyclooxigenases, COX-1 and COX-2, activities (19.65 and 48.02%, respectively). It also displayed biocompatibility on the immortalized and cancer cells, as no cytotoxic effect was observed. For the first time, the bioactive potential of this species was demonstrated, justifying its usage in pharmaceutical and food products as an alternative for some overexploited and endangered species from the Gentianaceae family.
Кључне речи:
Blackstonia perfoliata; Secoiridoid glycosides; Phenolics; Antimicrobial activity; Antioxidant activity; Anti-inflammatory effectИзвор:
Industrial Crops and Products, 2020, 145, 111974-Финансирање / пројекти:
- Симултана биоремедијација и соилификација деградираних простора, за очување природних ресурса биолошки активних супстанци и развој и производњу биоматеријала и дијететских производа (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43004)
- Физиолошка, хемијска и молекуларна анализа диверзитета одабраних ретких и угрожених биљних врста у циљу еx ситу заштите и продукције биолошки активних једињења (RS-MESTD-Basic Research (BR or ON)-173024)
DOI: 10.1016/J.INDCROP.2019.111974
ISSN: 0926-6690
WoS: 000518865400045
Scopus: 2-s2.0-85075869445
URI
https://www.sciencedirect.com/science/article/pii/S0926669019309847?via%3Dihubhttps://radar.ibiss.bg.ac.rs/handle/123456789/3562