Blackstonia perfoliata (L.) Huds. (Gentianaceae): A promising source of useful bioactive compounds
2020
Authors:
Mihailović, VladimirKatanić Stanković, Jelena S.
Jurić, Tatjana
Srećković, Nikola
Mišić, Danijela
Šiler, Branislav
Monti, Daria Maria
Imbimbo, Paola
Nikles, Stefanie
Pan, San-Po
Bauer, Rudolf
Document Type:
Article (Published version)
,
© 2019 Elsevier B.V.
Metadata
Show full item recordAbstract:
Blackstonia perfoliata (L.) Huds. is known as a highly bitter secoiridoid glycosides-containing plant and as a possible substitute for some Gentianaceae plants in herbal preparations. Nevertheless, its bioactive properties are still unknown. The present study aimed to characterize both, secoiridoid glycosides and phenolic constituents, and to investigate antioxidant, antimicrobial, anti-inflammatory, and cytotoxic activities of B. perfoliata methanolic extract. The secoiridoid glycosides swertiamarin, gentiopicrin, and sweroside were found to be the dominant compounds of the extract, while 23 phenolic compounds were identified in much lower concentrations. Among phenolics, flavanols were the most abundant, which represents a unique feature among Gentianaceae species. The extract showed moderate to weak antioxidant activity with better performance in inhibition of lipid peroxidation than in free radical scavenging activities. The extract showed generally better antifungal properties compared with its antibacterial potential. Also, B. perfoliata demonstrated in vitro anti-inflammatory activity, the extract (50 μg/mL) showed inhibition of cyclooxigenases, COX-1 and COX-2, activities (19.65 and 48.02%, respectively). It also displayed biocompatibility on the immortalized and cancer cells, as no cytotoxic effect was observed. For the first time, the bioactive potential of this species was demonstrated, justifying its usage in pharmaceutical and food products as an alternative for some overexploited and endangered species from the Gentianaceae family.
Keywords:
Blackstonia perfoliata; Secoiridoid glycosides; Phenolics; Antimicrobial activity; Antioxidant activity; Anti-inflammatory effectSource:
Industrial Crops and Products, 2020, 145, 111974-Funding / projects:
- Simultaneous Bioremediation and Soilification of Degraded Areas to Preserve Natural Resources of Biologically Active Substances, and Development and Production of Biomaterials and Dietetic Products (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43004)
- Physiological, chemical and molecular analysis of the diversity of selected rare and endangered plant species and application of biotechnology for ex situ conservation and production of biologically active compounds (RS-MESTD-Basic Research (BR or ON)-173024)
DOI: 10.1016/J.INDCROP.2019.111974
ISSN: 0926-6690
WoS: 000518865400045
Scopus: 2-s2.0-85075869445
URI
https://www.sciencedirect.com/science/article/pii/S0926669019309847?via%3Dihubhttps://radar.ibiss.bg.ac.rs/handle/123456789/3562