An Extremely Low Frequency Magnetic Field and Global Cerebral Ischemia Affect Pituitary ACTH and TSH Cells in Gerbils
2020
Authors:
Rauš Balind, SnežanaManojlović-Stojanoski, Milica
Šošić-Jurjević, Branka
Selaković, Vesna
Milošević, Verica
Petković, Branka
Document Type:
Article (Accepted Version)
,
© 2019 Bioelectromagnetics Society
Metadata
Show full item recordAbstract:
The neuroendocrine system can be modulated by a magnetic field and cerebral ischemia as external and internal stressors, respectively. This study deals with the separate or combined effects of an extremely low frequency (ELF) magnetic field (50 Hz, average magnetic field of 0.5 mT) for 7 days and global cerebral ischemia for 10 min on the morpho-functional features of pituitary adrenocorticotrophic (ACTH) and thyrotrophic (TSH) cells in 3-month-old gerbils. To determine the immediate and delayed effects of the applied stressors, measurements were made on the 7th and 14th days after the onset of the experiment. The ELF magnetic field and 10-min global cerebral ischemia, separately and particularly in combination, decreased (P < 0.05) the volume density of ACTH cells, while only in combination were intracellular ACTH content and plasma ACTH concentration increased (P < 0.05) on day 7. The ELF magnetic field elevated serum TSH concentration on day 7 and intracellular TSHβ content on day 14 (P < 0.05). Also, 10-min global cerebral ischemia alone increased serum TSH concentration (P < 0.05), while in combination with the ELF magnetic field it elevated (P < 0.05) intracellular TSHβ content on day 14. In conclusion, an ELF magnetic field and/or 10-min global cerebral ischemia can induce immediate and delayed stimulation of ACTH and TSH synthesis and secretion.
Note:
This is the pre-peer reviewed version of the following article: Rauš Balind S, Manojlović-Stojanoski M, Šošić-Jurjević B, Selaković V, Milošević V, Petković B. An Extremely Low Frequency Magnetic Field and Global Cerebral Ischemia Affect Pituitary ACTH and TSH Cells in Gerbils. Bioelectromagnetics. 2020;41(2):91-103, which has been published in final form at http://dx.doi.org/10.1002/bem.22237.
Related to: https://radar.ibiss.bg.ac.rs/handle/123456789/3764.
Keywords:
ACTH cells; TSH cells; Cerebral ischemia; Gerbils; Magnetic fieldSource:
Bioelectromagnetics, 2020, 41, 2, 91-103Funding / projects:
- The effects of select plant extracts, phytoestrogens, steroid and peptide hormones on the rat neuroendocrine system (RS-MESTD-Basic Research (BR or ON)-173009)
- The effects of magnetic fields and other environmental stressors on the physiological responses and behavior of different species (RS-MESTD-Basic Research (BR or ON)-173027)
- Medical Faculty MMA. Grant Number: MFMMA/11/16‐18
Related info:
DOI: 10.1002/bem.22237
ISSN: 0197-8462
PubMed: 31828821
WoS: 000502014500001
Scopus: 2-s2.0-85076388244
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/bem.22237https://radar.ibiss.bg.ac.rs/handle/123456789/3570