Graphene quantum dots as autophagy-inducing photodynamic agents
2012
Autori:
Marković, Zoran M.Ristić, Biljana Z.
Arsikin, Katarina M.
Klisić, Đorđe G.
Harhaji-Trajković, Ljubica
Todorović-Marković, Biljana M.
Kepić, Dejan P.
Kravić-Stevović, Tamara K.
Jovanović, Svetlana P.
Milenković, Marina M.
Milivojević, Dusan D.
Bumbaširević, Vladimir Z.
Dramićanin, Miroslav D.
Trajković, Vladimir S.
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2012 Elsevier Ltd.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
The excellent photoluminescent properties of graphene quantum dots (GQD) makes them suitable candidates for biomedical applications, but their cytotoxicity has not been extensively studied. Here we show that electrochemically produced GQD irradiated with blue light (470. nm, 1. W) generate reactive oxygen species, including singlet oxygen, and kill U251 human glioma cells by causing oxidative stress. The cell death induced by photoexcited GQD displayed morphological and/or biochemical characteristics of both apoptosis (phosphatidylserine externalization, caspase activation, DNA fragmentation) and autophagy (formation of autophagic vesicles, LC3-I/LC3-II conversion, degradation of autophagic target p62). Moreover, a genetic inactivation of autophagy-essential LC3B protein partly abrogated the photodynamic cytotoxicity of GQD. These data indicate potential usefulness of GQD in photodynamic therapy, but also raise concerns about their possible toxicity.
Ključne reči:
Apoptosis; Carbon; Cytotoxicity; Nanoparticle; PhotosensitisationIzvor:
Biomaterials, 2012, 33, 29, 7084-7092Finansiranje / projekti:
- Modulacija signalnih puteva koji kontrolišu intracelularni energetski balans u terapiji tumora i neuro-imuno-endokrinih poremećaja (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41025)
- Tanki slojevi jednoslojnih ugljeničnih nanotuba i grafena za primenu u elektronici (RS-MESTD-Basic Research (BR or ON)-172003)
- Uloga autofagije u regulaciji smrti tumorskih ćelija (RS-MESTD-Basic Research (BR or ON)-173053)
DOI: 10.1016/j.biomaterials.2012.06.060
ISSN: 0142-9612
PubMed: 22795854