Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs
2010
Authors:
Omar, KouatliGeronikaki, Athina
Zoumpoulakis, Panagiotis
Camoutsis, Charalabos
Soković, Marina
Ćirić, Ana
Glamočlija, Jasmina
Document Type:
Article (Published version)
,
© 2009 Elsevier Ltd.
Metadata
Show full item recordAbstract:
As part of ongoing studies in developing new antimicrobials, a class of structurally novel 4-thiazolidinone derivatives incorporating three known bioactive nuclei such as thiazole, thiazolidinone and adamantane was synthesized by the multi-step reaction protocol, already reported in the literature. NMR and Molecular Modeling techniques were employed for structure elucidation and Z/E potential isomerism configuration of the analogues. Evaluation of antibacterial and antifungal activity showed that almost all compounds exhibited better results than reference drugs thus they could be promising candidates for novel drugs.
Keywords:
4-Thiazolidinone; Antibacterial; Antifungal; Z/E isomerismSource:
Bioorganic & Medicinal Chemistry, 2010, 18, 1, 426-432
DOI: 10.1016/j.bmc.2009.10.041
ISSN: 0968-0896
PubMed: 19914077