Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs
2010
Аутори:
Omar, KouatliGeronikaki, Athina
Zoumpoulakis, Panagiotis
Camoutsis, Charalabos
Soković, Marina
Ćirić, Ana
Glamočlija, Jasmina
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2009 Elsevier Ltd.
Метаподаци
Приказ свих података о документуАпстракт:
As part of ongoing studies in developing new antimicrobials, a class of structurally novel 4-thiazolidinone derivatives incorporating three known bioactive nuclei such as thiazole, thiazolidinone and adamantane was synthesized by the multi-step reaction protocol, already reported in the literature. NMR and Molecular Modeling techniques were employed for structure elucidation and Z/E potential isomerism configuration of the analogues. Evaluation of antibacterial and antifungal activity showed that almost all compounds exhibited better results than reference drugs thus they could be promising candidates for novel drugs.
Кључне речи:
4-Thiazolidinone; Antibacterial; Antifungal; Z/E isomerismИзвор:
Bioorganic & Medicinal Chemistry, 2010, 18, 1, 426-432
DOI: 10.1016/j.bmc.2009.10.041
ISSN: 0968-0896
PubMed: 19914077