Chokeberry (Aronia melanocarpa) fruit extract modulates immune response in vivo and in vitro
2020
Authors:
Mićanović, DragicaSaksida, Tamara
Koprivica, Ivan
Vujičić, Milica
Despotović, Sanja
Šavikin, Katarina
Janković, Teodora
Stojanović, Ivana D.
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
Chokeberry (Aronia melanocarpa) is known for its anti-oxidant, anti-inflammatory and anti-diabetic properties. Since the effects of chokeberry extract on the immune response have been only sporadically assessed, our aim was to investigate chokeberry fruit water extract on the immune response in vivo and in vitro. When administered orally to healthy mice, the extract exerted immunomodulatory effects in the gut evidenced by the altered proportion of macrophages, dendritic cells and T cells. Importantly, oral consumption of the chokeberry extract resulted in blood glucose level increase in C57BL/6 mice with chemically-induced diabetes. These in vivo results were corroborated by observed up-regulation of nitric oxide and interelukin-1β production in macrophages and dendritic cells, up-regulated phagocytic activity of macrophages, increased T and B lymphocytes proportions and differentiation of interferon-γ-producing T cells in vitro. The obtained results imply that our chokeberry extract stimulates pro-inflammatory properties in immune cells of innate and adaptive immunity.
Keywords:
Aronia melanocarpa; Type 1 diabetes; Dendritic cells; Macrophages; T helper 1 cellsSource:
Journal of Functional Foods, 2020, 66, 103836-Funding / projects:
- Molecular mechanisms of physiological and pharmacological control of inflammation and cancer (RS-MESTD-Basic Research (BR or ON)-173013)
- Molecular mechanisms of physiological and pharmacological control of inflammation and cancer (RS-MESTD-Basic Research (BR or ON)-173013)
- Traditional and new products of cultivated and wild growing fruits and grape vines, and by-products durring processing, with special emphasis on indigenous varieties: chemical characterization and biological profile (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46013)
DOI: 10.1016/j.jff.2020.103836
ISSN: 1756-4646