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Chokeberry (Aronia melanocarpa) fruit extract modulates immune response in vivo and in vitro
dc.creator | Mićanović, Dragica | |
dc.creator | Saksida, Tamara | |
dc.creator | Koprivica, Ivan | |
dc.creator | Vujičić, Milica | |
dc.creator | Despotović, Sanja | |
dc.creator | Šavikin, Katarina | |
dc.creator | Janković, Teodora | |
dc.creator | Stojanović, Ivana D. | |
dc.date.accessioned | 2020-02-11T13:11:31Z | |
dc.date.available | 2020-02-11T13:11:31Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1756-4646 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3591 | |
dc.description.abstract | Chokeberry (Aronia melanocarpa) is known for its anti-oxidant, anti-inflammatory and anti-diabetic properties. Since the effects of chokeberry extract on the immune response have been only sporadically assessed, our aim was to investigate chokeberry fruit water extract on the immune response in vivo and in vitro. When administered orally to healthy mice, the extract exerted immunomodulatory effects in the gut evidenced by the altered proportion of macrophages, dendritic cells and T cells. Importantly, oral consumption of the chokeberry extract resulted in blood glucose level increase in C57BL/6 mice with chemically-induced diabetes. These in vivo results were corroborated by observed up-regulation of nitric oxide and interelukin-1β production in macrophages and dendritic cells, up-regulated phagocytic activity of macrophages, increased T and B lymphocytes proportions and differentiation of interferon-γ-producing T cells in vitro. The obtained results imply that our chokeberry extract stimulates pro-inflammatory properties in immune cells of innate and adaptive immunity. | en |
dc.language.iso | en | sr |
dc.publisher | Elsevier Ltd. | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46013/RS// | |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of Functional Foods | sr |
dc.subject | Aronia melanocarpa | sr |
dc.subject | Type 1 diabetes | sr |
dc.subject | Dendritic cells | sr |
dc.subject | Macrophages | sr |
dc.subject | T helper 1 cells | sr |
dc.title | Chokeberry (Aronia melanocarpa) fruit extract modulates immune response in vivo and in vitro | en |
dc.type | article | sr |
dc.rights.license | BY-NC-ND | sr |
dcterms.abstract | Стојановић, Ивана Д.; Гајић, Драгица; Саксида, Тамара; Копривица, Иван; Вујичић, Милица; Деспотовић, Сања; Шавикин, Катарина; Јанковић, Теодора; | |
dc.rights.holder | © 2020 Elsevier Ltd. | sr |
dc.citation.volume | 66 | |
dc.identifier.doi | 10.1016/j.jff.2020.103836 | |
dc.identifier.scopus | 2-s2.0-85078989112 | |
dc.identifier.wos | 000518708200032 | |
dc.citation.apa | Gajic, D., Saksida, T., Koprivica, I., Vujicic, M., Despotovic, S., Savikin, K., et al. (2020). Chokeberry (Aronia melanocarpa) fruit extract modulates immune response in vivo and in vitro. Journal of Functional Foods, 66, 103836. | |
dc.citation.vancouver | Gajic D, Saksida T, Koprivica I, Vujicic M, Despotovic S, Savikin K, Jankovic T, Stojanovic I. Chokeberry (Aronia melanocarpa) fruit extract modulates immune response in vivo and in vitro. J Funct Foods. 2020;66:103836. | |
dc.citation.spage | 103836 | |
dc.type.version | publishedVersion | sr |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/5923/bitstream_5923.pdf | |
dc.citation.rank | M21 |