Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity.
2020
Authors:
Tucović, DinaMirkov, Ivana
Kulaš, Jelena
Zeljković, Milica
Popović, Dušanka
Zolotarevski, Lidija
Đuđjić, Slađana
Mutić, Jelena
Kataranovski, Milena
Popov Aleksandrov, Aleksandra
Document Type:
Article (Published version)
,
© 2020 Elsevier B.V.
Metadata
Show full item recordAbstract:
Adverse effects of non-occupational exposure to cadmium (Cd) are increasingly acknowledged. Since our previous study has showed that orally acquired Cd affects skin, the contribution of genetic background to dermatotoxicity of oral cadmium was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), which differed in response to chemicals. While similar accumulation of Cd in the skin of both strains was noted, the skin response to the metal differed. DA rat individuals mounted antioxidant enzyme defense in the skin already at lower Cd dose, in contrast to AO rats which reacted to higher metal dose solely (and less pronounced), implying higher susceptibility of DA strain to Cd dermatotoxicity. Epidermal cells from both strains developed stress response, but higher intensity of antioxidant response in AO rats implied this strain`s better ability to defend against Cd insult. Cd induced epidermal cells' proinflammatory cytokine response only in DA rats. Increased IL-10 seems responsible for the lack of response in AO rats. Differences in the pattern of skin/epidermal cell responsiveness to cadmium give a new insight into repercussion of genetic variability to dermatotoxicity of orally acquired cadmium, bearing relevance for variations in the link between dietary cadmium and inflammation-based skin pathologies.
Keywords:
Anti-oxidative response; DA and AO rats; Immune response; Oral cadmium; Skin and epidermal cells; Stress responseSource:
Environmental Toxicology and Pharmacology, 2020, 75, 103326-Funding / projects:
- Immunomodulatory effects of environmental xenobiotics and biotic factors on the populations of mouse-like rodents (RS-MESTD-Basic Research (BR or ON)-173039)
DOI: 10.1016/j.etap.2020.103326
ISSN: 1382-6689
PubMed: 31924569
WoS: 000527317100009
Scopus: 2-s2.0-85077378172
URI
internal-pdf://Tucovic et al. - 2020 - Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and infla.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/31924569
https://radar.ibiss.bg.ac.rs/handle/123456789/3594