Coprinopsis atramentaria extract, its organic acids, and synthesized glucuronated and methylated derivatives as antibacterial and antifungal agents
2014
Аутори:
Heleno, Sandrina A.Ferreira, Isabel C. F. R.
Ćirić, Ana
Glamočlija, Jasmina
Martins, Anabela
Queiroz, Maria Joao R. P.
Soković, Marina
Тип документа:
Чланак у часопису (Рецензирана верзија)
,
© The Royal Society of Chemistry 2014
Метаподаци
Приказ свих података о документуАпстракт:
Despite the available data regarding antimicrobial activity of phenolic acids, studies dealing with the effects of their metabolites or derivatives are scarce. Therefore, the antimicrobial and demelanizing activities of Coprinopsis atramentaria extract, its organic acids, and methylated and glucuronated derivatives were evaluated. The antifungal activity was stronger than the antibacterial effects. In general, individual compounds (mostly organic acids) exhibited higher activity than the extract and even higher than the standards used in the assays. Methylated derivatives presented the highest demelanizing activity toward Aspergillus niger, A. fumigatus and Penicillium verrucosum var. cyclopium. The inclusion of methyl groups in the parental compound (CoAM1, CoAM2 and CoAM3) strongly increased antibacterial and antifungal activities of CoA, while the inclusion of acetyl groups (CoAGP) increased the antifungal activity but the antibacterial properties were maintained. For HA and CA, the inclusion of methyl groups (HAM1, HAM2, HAM3 and CAM) increased the demelanizing activity, but decreased the antimicrobial properties. The present work contributes to the knowledge of the mechanisms involved in the antimicrobial properties of organic acids namely, phenolic acids, usually present in mushrooms. Organic acids, and methylated and glucuronated derivatives could be used as antimicrobial agents.
Напомена:
This is the accepted manuscript version of the following article: Heleno SA, Ferreira ICFR, Ćirić A, Glamočlija J, Martins A, Queiroz MJRP, Soković M. Coprinopsis atramentaria extract, its organic acids, and synthesized glucuronated and methylated derivatives as antibacterial and antifungal agents. Food Funct. 2014;5(10):2521-8.. http://dx.doi.org/10.1039/c4fo00490f.
Извор:
Food & Function, 2014, 5, 10, 2521-2528Финансирање / пројекти:
- Карактеризација и примена метаболита гљива и утврђивање потенцијала нових биофунгицида (RS-MESTD-Basic Research (BR or ON)-173032)
DOI: 10.1039/c4fo00490f
ISSN: 2042-650X
PubMed: 25131614
WoS: 000343023300016
Scopus: 2-s2.0-84907808125
URI
https://radar.ibiss.bg.ac.rs/handle/123456789/2149https://radar.ibiss.bg.ac.rs/handle/123456789/3611