Pituitary Hyperplasia, Hormonal Changes and Prolactinoma Development in Males Exposed to Estrogens — An Insight From Translational Studies
2020
Аутори:
Šošić-Jurjević, BrankaAjdžanović, Vladimir
Miljić, Dragana
Trifunović, Svetlana
Filipović, Branko
Stanković, Sanja
Bolevich, Sergey
Jakovljević, Vladimir
Milošević, Verica
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Estrogen signaling plays an important role in pituitary development and function. In sensitive rat or mice strains of both sexes, estrogen treatments promote lactotropic cell proliferation and induce the formation of pituitary adenomas (dominantly prolactin or growth-hormone-secreting ones). In male patients receiving estrogen, treatment does not necessarily result in pituitary hyperplasia, hyperprolactinemia or adenoma development. In this review, we comprehensively analyze the mechanisms of estrogen action upon their application in male animal models comparing it with available data in human subjects. Sex-specific molecular targets of estrogen action in lactotropic (PRL) cells are highlighted in the context of their proliferative and secretory activity. In addition, putative effects of estradiol on the cellular/tumor microenvironment and the contribution of postnatal pituitary progenitor/stem cells and transdifferentiation processes to prolactinoma development have been analyzed. Finally, estrogen-induced morphological and hormone-secreting changes in pituitary thyrotropic (TSH) and adrenocorticotropic (ACTH) cells are discussed, as well as the putative role of the thyroid and/or glucocorticoid hormones in prolactinoma development, based on the current scarce literature.
Кључне речи:
Pituitary gland; Estrogen; Prolactinoma; Men; Rat; Microenvironment; Folliculo-stellate cells; Prolactin; Thyroid-stimulating hormone; Adrenocorticotropic hormoneИзвор:
International Journal of Molecular Sciences, 2020, 21, 6, 2024-Финансирање / пројекти:
- Одговор неуроендокриног система пацова на одабране биљне екстракте, фитоестрогене, стероидне и пептидне хормоне (RS-MESTD-Basic Research (BR or ON)-173009)
DOI: 10.3390/ijms21062024
ISSN: 1422-0067