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Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats
dc.creator | Đurašević, Siniša | |
dc.creator | Nikolić, Gorana | |
dc.creator | Todorović, Ana | |
dc.creator | Drakulić, Dunja | |
dc.creator | Pejić, Snežana | |
dc.creator | Martinović, Vesna | |
dc.creator | Mitić-Ćulafić, Dragana | |
dc.creator | Milić, Dragana | |
dc.creator | Kop, Tatjana J. | |
dc.creator | Jasnić, Nebojša | |
dc.creator | Đorđević, Jelena | |
dc.creator | Todorović, Zoran | |
dc.date.accessioned | 2020-04-22T09:52:09Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0278-6915 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3645 | |
dc.description.abstract | The effects of twelve weeks of supplementation with fullerene C60 olive/coconut oil solution on a broad spectrum of parameters in rats were examined. The tissue bioaccumulation of C60 was shown to be tissue-specific, with the liver, heart, and adrenal glands being the organs of the greatest, and the kidney, brain, and spleen being the organs of the smallest accumulation. C60 did not change aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase serum activities level, nor the damage of liver cells DNA. There were no effects of fullerene on prooxidant-antioxidant balance in the liver, kidney, spleen, heart, and brain, nor any visible harmful effects on the liver, heart, aorta, spleen, kidney, and small intestine histology. Fullerene changed the gut microbiota structure towards the bacteria that ameliorate lipid homeostasis, causing a serum triglycerides concentration decrease. However, C60 significantly increased the insulin resistance, serum ascorbate oxidation, and brain malondialdehyde and advanced oxidation protein products level. The deteriorative effects of C60 on the brain and serum could be attributed to the specific physicochemical composition of these tissues, potentiating the C60 aggregation or biotransformation as the key element of its pro-oxidative action. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172002/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41027/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173023/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173020/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172058/RS// | |
dc.rights | restrictedAccess | |
dc.source | Food and Chemical Toxicology | |
dc.subject | Fullerene C60 | |
dc.subject | Glucose homeostasis | |
dc.subject | Gut microbiota | |
dc.subject | Lipid homeostasis | |
dc.subject | Rats | |
dc.title | Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Милић, Драгана; Ђурашевић, Синиша; Николић, Горана; Пејић, Снежана; Мартиновић, Весна; Коп, Татјана Ј.; Јаснић, Небојша; Митић-Ћулафић, Драгана; Ђорђевић, Јелена; Тодоровић, Зоран; Тодоровић, Aна; Дракулић, Дуња; Еффецтс оф фуллерене Ц60 супплементатион он гут мицробиота анд глуцосе анд липид хомеостасис ин ратс; | |
dc.rights.holder | © 2020 Elsevier Ltd | |
dc.citation.volume | 140 | |
dc.identifier.doi | 10.1016/j.fct.2020.111302 | |
dc.identifier.pmid | 32234425 | |
dc.identifier.scopus | 2-s2.0-85082680875 | |
dc.identifier.wos | 000535895100014 | |
dc.citation.apa | Đurašević, S., Nikolić, G., Todorović, A., Drakulić, D., Pejić, S., Martinović, V., et al. (2020). Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats. Food and Chemical Toxicology, 140, 111302. | |
dc.citation.vancouver | Đurašević S, Nikolić G, Todorović A, Drakulić D, Pejić S, Martinović V, Mitić-Ćulafić D, Milić D, Kop TJ, Jasnić N, Đorđević J, Todorović Z. Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats. Food Chem Toxicol. 2020;140:111302. | |
dc.citation.spage | 111302 | |
dc.type.version | publishedVersion | |
dc.citation.rank | M21 |