Changes in mouse thymus after exposure to tube-restraint stress
2020
Preuzimanje 🢃
Autori:
Drljača, JovanaVejnović, Ana-Marija
Miljković, Dejan
Popović, Milan
Rakić, Dušica
Sekulić, Slobodan
Čapo, Ivan
Petković, Branka
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
The thymus is the primary lymphoid organ involved in the regulation of the immune and endocrine systems. It is particularly sensitive to various types of stress, which induce its atrophy. This study deals with the effect of repeated restraint stress on the weight, proliferation and apoptosis of the thymus in mice. During restraint, the animals were placed in 50-mL conical plastic tubes for 2 h every day for either 10 or 20 consecutive days. A significant reduction in thymus weight along with decreased cellularity and pronounced atrophy of the cortical part of the thymus was observed in animals exposed to repeated tube-restraint stress for 10 and 20 consecutive days. The observed changes in the thymus were the same, regardless of the number of days of exposure to stress. These findings provide a more comprehensive view of repeated tube-restraint, with special emphasis on its duration on stress-induced thymus atrophy. The presented findings could serve as a basis for further studies aimed at identifying the mechanisms responsible for the adaptive response of the thymus after repeated exposure to stress.
Ključne reči:
Immobilization; Physical restraint; Thymus; Proliferation; ApoptosisIzvor:
Archives of Biological Sciences, 2020, 72, 1, 5-11Finansiranje / projekti:
- Neurološki razvoj kod prenatalne izloženosti ploda antiepileptičnoj terapiji (RS-MESTD-Basic Research (BR or ON)-175006)
- Provincial Secretariat for Higher Education and Scientific Research of Vojvodina (142-451-3630/2017-01/02)
DOI: 10.2298/abs190716060d
ISSN: 0354-4664
WoS: 000524505000001
Scopus: 2-s2.0-85086597445
URI
http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/4473https://radar.ibiss.bg.ac.rs/handle/123456789/3655