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Changes in mouse thymus after exposure to tube-restraint stress
dc.creator | Drljača, Jovana | |
dc.creator | Vejnović, Ana-Marija | |
dc.creator | Miljković, Dejan | |
dc.creator | Popović, Milan | |
dc.creator | Rakić, Dušica | |
dc.creator | Sekulić, Slobodan | |
dc.creator | Čapo, Ivan | |
dc.creator | Petković, Branka | |
dc.date.accessioned | 2020-04-29T12:26:30Z | |
dc.date.available | 2020-04-29T12:26:30Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0354-4664 | |
dc.identifier.uri | http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/4473 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3655 | |
dc.description.abstract | The thymus is the primary lymphoid organ involved in the regulation of the immune and endocrine systems. It is particularly sensitive to various types of stress, which induce its atrophy. This study deals with the effect of repeated restraint stress on the weight, proliferation and apoptosis of the thymus in mice. During restraint, the animals were placed in 50-mL conical plastic tubes for 2 h every day for either 10 or 20 consecutive days. A significant reduction in thymus weight along with decreased cellularity and pronounced atrophy of the cortical part of the thymus was observed in animals exposed to repeated tube-restraint stress for 10 and 20 consecutive days. The observed changes in the thymus were the same, regardless of the number of days of exposure to stress. These findings provide a more comprehensive view of repeated tube-restraint, with special emphasis on its duration on stress-induced thymus atrophy. The presented findings could serve as a basis for further studies aimed at identifying the mechanisms responsible for the adaptive response of the thymus after repeated exposure to stress. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175006/RS// | |
dc.relation | Provincial Secretariat for Higher Education and Scientific Research of Vojvodina (142-451-3630/2017-01/02) | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Archives of Biological Sciences | |
dc.subject | Immobilization | |
dc.subject | Physical restraint | |
dc.subject | Thymus | |
dc.subject | Proliferation | |
dc.subject | Apoptosis | |
dc.title | Changes in mouse thymus after exposure to tube-restraint stress | en |
dc.type | article | en |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Поповић, Милан; Миљковић, Дејан; Петковић, Бранка; Чапо, Иван; Секулић, Слободан; Ракић, Дусица; Дрљача, Јована; Вејновић, Aна-Марија; | |
dc.rights.holder | © 2020 by the Serbian Biological Society | |
dc.citation.issue | 1 | |
dc.citation.volume | 72 | |
dc.identifier.doi | 10.2298/abs190716060d | |
dc.identifier.scopus | 2-s2.0-85086597445 | |
dc.identifier.wos | 000524505000001 | |
dc.citation.apa | Drljača, J., Vejnović, A.-M., Miljković, D., Popović, M., Rakić, D., Sekulić, S., et al. (2020). Changes in mouse thymus after exposure to tube-restraint stress. Archives of Biological Sciences, 72(1), 5–11. | |
dc.citation.vancouver | Drljača J, Vejnović A-M, Miljković D, Popović M, Rakić D, Sekulić S, Čapo I, Petković B. Changes in mouse thymus after exposure to tube-restraint stress. Arch Biol Sci. 2020;72(1):5–11. | |
dc.citation.spage | 5 | |
dc.citation.epage | 11 | |
dc.type.version | publishedVersion | |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/6128/ABS-72-1-005-011.pdf | |
dc.citation.rank | M23 |