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Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis
dc.creator | Mandim, Filipa | |
dc.creator | Petropoulos, Spyridon A. | |
dc.creator | Giannoulis, Kyriakos D. | |
dc.creator | Dias, Maria Inês | |
dc.creator | Fernandes, Ângela | |
dc.creator | Pinela, José | |
dc.creator | Kostić, Marina | |
dc.creator | Soković, Marina | |
dc.creator | Barros, Lillian | |
dc.creator | Santos-Buelga, Celestino | |
dc.creator | Ferreira, Isabel C.F.R. | |
dc.date.accessioned | 2020-05-14T11:36:39Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0963-9969 | |
dc.identifier.uri | https://linkinghub.elsevier.com/retrieve/pii/S0963996920303069 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3674 | |
dc.description.abstract | Cynara cardunculus L. (cardoon) has several health benefits mainly attributed to its abundance in polyphenols. In this study, cardoon heads (capitula) were harvested in Greece during the flowering stage, and the hydroethanolic extracts were assessed in terms of phenolic compounds composition and antioxidant, cytotoxic, anti-inflammatory, and antimicrobial activities. The phenolic profile was evaluated by HPLC-DAD-ESI/MS to better understand the seasonal changes in the individual compound levels and how these changes correlate with bioactive properties. The main phenolic compounds identified were caffeoylquinic and dicaffeoylquinic acid derivatives. Immature heads (Car A: principal growth stage (PGS) 5) had the highest phenolic content (34.3 mg/g) and cytotoxic (GI50 of 69–268 µg/mL) and anti-inflammatory (IC50 of 183 µg/mL) activities. Sample Car D (PGS 6/7) revealed the highest antioxidant (IC50 of 23–227 µg/mL) and antifungal (MIC of 0.26–0.51 mg/mL) potential. Regarding the antibacterial activity, Car E (PGS 7) revealed the best results (MIC of 0.59–1.18 mg/mL). This study suggests that the maturity stage of the plant influences the phenolic composition and bioactivity. | en |
dc.publisher | Elsevier Ltd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173032/RS// | |
dc.relation | Foundation for Science and Technology | |
dc.relation | 0377_Iberphenol_6_E | |
dc.relation | TRANSCoLAB (0612_TRANS_CO_LAB_2_P) | |
dc.rights | restrictedAccess | |
dc.source | Food Research International | |
dc.subject | Anti-inflammatory activity | |
dc.subject | Antimicrobial properties | |
dc.subject | Bioactive properties | |
dc.subject | Cynara cardunculus (L.) | |
dc.subject | Phenolic compounds | |
dc.subject | Seasonal variation | |
dc.title | Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Костић, Марина; Гианноулис, Кyриакос Д.; Сантос-Буелга, Целестино; Баррос, Лиллиан; Соковић, Марина; Пинела, Јосé; Фернандес, Âнгела; Диас, Мариа Инêс; Петропоулос, Спyридон A.; Мандим, Филипа; Ферреира, Исабел Ц.Ф.Р.; | |
dc.rights.holder | © 2020 Published by Elsevier Ltd. | |
dc.citation.volume | 134 | |
dc.identifier.doi | 10.1016/j.foodres.2020.109281 | |
dc.identifier.scopus | 2-s2.0-85084110847 | |
dc.identifier.wos | 000539366100053 | |
dc.citation.apa | Mandim, F., Petropoulos, S. A., Giannoulis, K. D., Dias, M. I., Fernandes, Â., Pinela, J., et al. (2020). Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis. Food Research International, 134, 109281. | |
dc.citation.vancouver | Mandim F, Petropoulos SA, Giannoulis KD, Dias MI, Fernandes Â, Pinela J, Kostic M, Soković M, Barros L, Santos-Buelga C, Ferreira ICFR. Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis. Food Res Int. 2020;134:109281. | |
dc.citation.spage | 109281 | |
dc.type.version | publishedVersion | |
dc.citation.rank | aM21 |