Plant Extracts and Isolated Compounds Reduce Parameters of Oxidative Stress Induced by Heavy Metals: An up-to-Date Review on Animal Studies.
2020
Аутори:
Mirkov, IvanaStojković, Dejan
Popov Aleksandrov, Aleksandra
Ivanov, Marija
Kostić, Marina
Glamočlija, Jasmina
Soković, Marina
Тип документа:
Чланак у часопису (Објављена верзија)
,
© Bentham Science Publishers
Метаподаци
Приказ свих података о документуАпстракт:
BACKGROUND Heavy metals are elements that are naturally found in the earth. They are used in many modern-day applications in agriculture, medicine, and industry. Heavy metal poisoning occurs when the body's soft tissues absorb too much of a particular metal. The heavy metals of interest for this review paper were cadmium, arsenic, mercury, and lead since these are the most common metals that the human body can absorb in toxic amounts. Different plant species were investigated in recent years for their effect on oxidative stress parameters after intoxication with heavy metals. OBJECTIVES This review paper is focused on the current update to research on heavy metals induced oxidative stress in animal models and improvement of the oxidative stress parameters upon/co-/after treatment with different plant extracts and isolated compounds. METHODS The available literature was screened for the novel data regarding the influence of plant extracts and compounds on heavy metals induced oxidative stress. For that purposes Scopus database was used, looking for the publications in the last 5-10 years with the key terms: plant extracts, oxidative stress, in vivo, cadmium, lead, mercury and arcenic. RESULTS Various parameters of oxidative stress were investigated, and their improvement with plant extracts/ compounds was observed in the brain, lungs, kidneys, liver, uterus, testis, thymus, spleen, heart, skin and blood of experimental animals. Common parameters used to determine oxidative stress in animals were: superoxide dismutase; catalase; reduced glutathione; glutathione reductase; glutathione-S-transferase; glutathione peroxidase; lipid peroxidation; oxidized glutathione; malondialdehyde; xanthine oxidase; nonprotein-soluble thiol; thioredoxin reductase; total sulphydryl group; nitric oxide; γ-glutamyl cysteine synthetase. CONCLUSION The most investigated species for antioxidant effects upon intoxication with heavy metals seem to be Allium sp., Bacopa monniera, Camellia sinensis, Moringa oleifera, Vitis vinifera and Zingiber officinale. According to literature data, the most promising effect to alleviate symptoms of intoxication was achieved with proanthocyanidins obtained from Vitis vinifera.
Кључне речи:
Cadmium; Arsenic; Lead; Mercury; Oxidative stress; Plant extractsИзвор:
Current Pharmaceutical Design, 2020, 26, 16, 1799-1815Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
DOI: 10.2174/1381612826666200407163408
ISSN: 1873-4286
PubMed: 32264808
WoS: 000535934800005
Scopus: 2-s2.0-85085629805
URI
http://www.eurekaselect.com/180769/articlehttp://www.ncbi.nlm.nih.gov/pubmed/32264808
https://radar.ibiss.bg.ac.rs/handle/123456789/3697