The antioxidant potential of Lactarius deterrimus in diabetes
2020
Аутори:
Arambašić Jovanović, JelenaMihailović, Mirjana
Dinić, Svetlana
Grdović, Nevena
Uskoković, Aleksandra
Poznanović, Goran
Vidaković, Melita
Остала ауторства
Preedy, Victor R.Тип документа:
Поглавље у монографији (Објављена верзија)
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© 2020 Elsevier Inc.
Метаподаци
Приказ свих података о документуАпстракт:
Diabetes is characterized by impaired pancreatic insulin production or an insufficient cellular response to insulin. Hyperglycemia is the main cause of diabetic complications affecting vascular system, kidneys, eyes, peripheral nerves, liver and gastrointestinal system. Hyperglycemia induces overproduction of reactive oxygen species, resulting in impaired cellular function and altered cell signaling. High intracellular glucose levels activate the formation of advanced glycation end-products, the polyol pathway, the hexosamine pathway, and the protein kinase C pathway, affecting gene expression and activity of different regulator proteins. Medicinal mushrooms as source of metabolites (minerals, vitamins, polyphenols, flavonoids, terpenes, alkaloids) have been used in traditional medicine in diabetes treatment for centuries. Lactarius species exhibit a variety of biological activities, including antioxidant, antitumor, and immunostimulatory actions. In this chapter the antioxidant capacity of Lactarius deterrimus and its potential to attenuate the processes that underlie the development and progression of diabetes and diabetes-induced complications will be examined.
Кључне речи:
Diabetes; Lactarius deterrimus; Hyperglycemia; Oxidative stress; β-cell survival; Advanced glycated end-products; Reactive oxygen speciesФинансирање / пројекти:
- Сигнални молекули у дијабетесу: идентификација потенцијалних биолошких маркера укључених у модификацију и интеграцију сигналних путева у циљу предикције и интервенције у дијабетесу (RS-MESTD-Basic Research (BR or ON)-173020)
У:
- Preedy VR, editor. Diabetes: Oxidative Stress and Dietary Antioxidants. 2nd ed. San Diego : Elsevier Science & Technology; 2020. p. 265-73.