Redox Regulation of Tolerogenic Dendritic Cells and Regulatory T Cells in the Pathogenesis and Therapy of Autoimmunity
2021
Тип документа:
Чланак у часопису (Рецензирана верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Significance: Autoimmune diseases are progressively affecting westernized societies, as
the proportion of individuals suffering from autoimmunity is steadily increasing over the
past decades. Understanding the role of reactive oxygen species (ROS) in modulation of
the immune response in the pathogenesis of autoimmune disorders is of utmost
importance. The focus of this review is the regulation of ROS production within tolerogenic
dendritic cells (tolDC) and regulatory T (Treg) cells that have the essential role in the
prevention of autoimmune diseases and significant potency in their therapy.
Recent Advances: It is now clear that ROS are extremely important for the proper function
of both DC and T cells. Antigen processing/presentation and the ability of DC to activate T
cells depend upon the ROS availability. Treg differentiation, suppressive function and
stability are profoundly influenced by ROS presence.
Critical Issues: Although a plethora of results on the relation between ROS and immune
cells exists, it remains unclear whether ROS modulation is a productive way for skewing T
cells and DC towards a tolerogenic phenotype. Also, the possibility of ROS modulation for
enhancement of regulatory properties of DC and Treg during their preparation for use in
cellular therapy has to be clarified.
Future Directions: Studies of DC and T cell redox regulation should allow for the
improvement of the therapy of autoimmune diseases. This could be achieved through the
direct therapeutic application of ROS modulators in autoimmunity or indirectly, through
ROS-dependent enhancement of tolDC and Treg preparation for cell-based
immunotherapy.
Напомена:
Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/ars.2019.7999
Кључне речи:
Reactive oxygen species; Dendritic cells; T cells; Tolerogenic dendritic cells; T regulatory cellsИзвор:
Antioxidants & Redox Signaling, 2021, 34, 5, 364-382Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
Повезане информације:
- Друга верзија
https://radar.ibiss.bg.ac.rs/handle/123456789/4234
DOI: 10.1089/ars.2019.7999
ISSN: 1523-0864
PubMed: 32458699