Theta burst stimulation ameliorates symptoms of experimental autoimmune encephalomyelitis and attenuates reactive gliosis.
2020
Аутори:
Dragić, MiloradZeljković, Milica
Stevanović, Ivana
Ilić, Tihomir
Ilić, Nela
Nedeljković, Nadezda
Ninković, Milica
Тип документа:
Чланак у часопису (Објављена верзија)
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© 2020 Elsevier Inc.
Метаподаци
Приказ свих података о документуАпстракт:
Multiple sclerosis (MS) is a chronic neurodegenerative disease caused by inflammatory processes in the central nervous system (CNS). Decades of research led to discovery of several disease-modifying therapeutics strategies with moderate success. Experimental autoimmune encephalomyelitis (EAE) is currently the most commonly used experimental model for MS and for studying various therapeutic approaches. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neurostimulation technique with multiple beneficial effects on healthy as well as CNS with pathology. However, the molecular and cellular mechanisms of rTMS on acute EAE are scarce. Our study demonstrated beneficial effects of theta-burst stimulation (TBS), an experimental paradigm of rTMS, on disease course of acute EAE. TBS treatment attenuated reactive gliosis, restored myelin sheet and down-regulated expression of vimentin in EAE rats. These effects were reflected through reduced clinical parameters, shorter duration of illness and days spent in paralysis. Based on our research, rTMS deserves further considerations for its neuroprotective effect on EAE, and is an excellent candidate for further research and points that it could be used for more than for simple symptomatic therapy.
Кључне речи:
Attenuation; EAE; Myelin; Reactive gliosis; Vimentin; rTMSИзвор:
Brain Research Bulletin, 2020, 162, 208-217Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200178 (Универзитет у Београду, Биолошки факултет) (RS-MESTD-inst-2020-200178)
- University of Defense (Grant No MFVMA/01/18-20)
DOI: 10.1016/j.brainresbull.2020.06.013
ISSN: 0361-9230
PubMed: 32599126