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Spontaneous cerebellar activity and its role in neurotoxicity
Spontana aktivnost malog mozga i njegova uloga u neurotoksičnosti
dc.creator | Martać, Ljiljana | |
dc.creator | Stojadinović, Gordana | |
dc.creator | Petković, Branka | |
dc.date.accessioned | 2020-07-15T11:15:44Z | |
dc.date.available | 2020-07-15T11:15:44Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0025-8105 | |
dc.identifier.uri | http://www.doiserbia.nb.rs/issue.aspx?issueid=3008 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3773 | |
dc.description.abstract | Introduction. In performed experiments, the parietal electrocortical activity of the cerebral cortex and the activity of the cerebellar cortex were simultaneously recorded. The main purpose was to compare their spontaneous activity, as the recording was conducted during anesthesia. Material and Methods. We used 2–3 months old rats weighing 200 – 350 g. Two groups of rats with same characteristics were made. The first group of 15 rats (control group) was recorded under anesthesia and there was a change in spectral power in accordance with frequency ranges. The second group of 30 rats was recorded under the same experimental conditions, but the rats were treated intraperitoneally by aluminium chloride hexahydrate solution or with 1.5% solution of aluminium chloride hexahydrate per os. Discussion. Changes in spontaneous activity of the cerebellum during aluminium intoxication were compared with control values. It was shown that lesion and neurotoxicity during stable anesthesia led to desynchronization of the cerebellar activity. This is described by the change in fractal dimension of cerebellar electrocortical activity. The assumption is that the inhibition caused by anesthetic is compensated during aluminium intoxication. Conclusion. The cerebellum plays a role in compensation through changes in spontaneous activity. This response involves an increase in the value of fractal dimension of cerebellar electrocortical activity which is reduced in neurotoxicity. | en |
dc.description.abstract | Uvod. U eksperimentima je uporedo registrovana elektrokortikalna aktivnost parijetalne kore velikog mozga, kao i aktivnost kore malog mozga. Cilj je da se uporedi njihova spontana aktivnost jer se registrovanje vrši u anesteziji. Materijal i metode. U istraživanju smo koristili pacove starosti 2 - 3 meseca, telesne mase 200 - 350 g. Formirane su dve grupe pacova sa istim karakteristikama. Kod prve grupe, koju cinilo je 15 pacova (kontrolna grupa) ispitivanje je rađeno u anesteziji, zabeležene su promene spektralne snage u skladu sa obimom frekvencije. Druga grupa od 30 pacova je ispitivana pod istim eksperimentalnim uslovima, ali su pacovi tretirani rastvorom aluminijum hlorid heksahidrata, ili 1.5 % rastvorom aluminijum hlorid heksahidrata per os. Diskusija. Promena spontane aktivnosti malog mozga u uslovima intoksikacije aluminijumom je poređena sa kontrolnim vrednostima. Pokazano je da lezija i neurotoksičnost u uslovima stabilne anestezije dovode do desinhronizacije aktivnosti malog mozga. Ovo je opisano promenom fraktalne dimenzije elektrokortikalne aktivnosti. Pretpostavka je da se inhibicija izazvana anestetikom kompenzuje u uslovima intoksikacije aluminijumom. Zaključak. Mali mozak ima ulogu u kompenzaciji putem promene spontane aktivnosti. Ovakav odgovor podrazumeva povećanje vrednosti fraktalne dimenzije elektrokortikalne aktivnosti malog mozga koja je u uslovima neurotoksičnosti smanjena. | sr |
dc.language.iso | en | |
dc.publisher | Društvo lekara Vojvodine Srpskog lekarskog društva | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175006/RS// | |
dc.rights | openAccess | |
dc.source | Medical Review | en |
dc.subject | Aluminum | en |
dc.subject | Cerebellum | en |
dc.subject | Action Potentials | en |
dc.subject | Neurotoxicity Syndromes | en |
dc.subject | Neuronal Plasticity | en |
dc.subject | Adaptation, Psychological | en |
dc.subject | Rats | en |
dc.subject | Anesthesia | en |
dc.subject | Aluminijum | sr |
dc.subject | Mali mozak | sr |
dc.subject | Spontana aktivnost | sr |
dc.subject | Neurotoksični sindromi | sr |
dc.subject | Neuroplastičnost | sr |
dc.subject | Adaptacija | sr |
dc.subject | Pacovi | sr |
dc.subject | Anestezija | sr |
dc.title | Spontaneous cerebellar activity and its role in neurotoxicity | en |
dc.title | Spontana aktivnost malog mozga i njegova uloga u neurotoksičnosti | sr |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Петковић, Бранка; Стојадиновић, Гордана; Мартаћ, Љиљана; Спонтана активност малог мозга и његова улога у неуротоксичности; Спонтана активност малог мозга и његова улога у неуротоксичности; | |
dc.rights.holder | ® Društvo lekara Vojvodine Srpskog lekarskog društva | |
dc.citation.issue | 9-10 | |
dc.citation.volume | 70 | |
dc.identifier.doi | 10.2298/MPNS1710283M | |
dc.citation.spage | 283 | |
dc.citation.epage | 289 | |
dc.type.version | publishedVersion | en |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/6468/bitstream_6468.pdf | |
dc.citation.rank | M51 |