Short- and Long-Term Exposure to Alternating Magnetic Field (50 Hz, 0.5 mT) Affects Rat Pituitary ACTH Cells: Stereological Study
2016
Authors:
Rauš Balind, SnežanaManojlović-Stojanoski, Milica
Milošević, Verica
Todorović, Dajana
Nikolić, Ljiljana
Petković, Branka
Document Type:
Article (Published version)
,
© 2014 Wiley Periodicals, Inc.
Metadata
Show full item recordAbstract:
The aim of the present study was to determine does extremely low frequency magnetic field (ELF-MF, 50 Hz, 0.5 mT) affect pituitary adrenocorticotroph (ACTH) cells in adult animals. We performed two series of experiments: (1) short-term exposure of 3-month-old rats to ELF-MF for 1 and 7 days, and (2) long-term exposure of rats to ELF-MF from their conception to 3 months of age. Stereological study was performed on immunolabeled pituitary ACTH cells. The total number and volume of ACTH cells, the volume of their nuclei and pituitary volume were measured. ELF-MF exposure for 1 day significantly decreased total number and volume of ACTH cells, the volume of their nuclei, as well as pituitary volume. ELF-MF exposure for 7 days significantly reduced only the volume of ACTH cells. Life-long exposure to ELF-MF induced decrease in the volume of ACTH cells and pituitary volume. We can conclude that the applied ELF-MF has a strong influence on morphometrical parameters of the pituitary ACTH cells and could be considered as a stressogenic factor.
Keywords:
Extremely low frequency magnetic field; ACTH cells; Stereology; PituitarySource:
Environmental Toxicology, 2016, 31, 4, 461-468Funding / projects:
- The effects of magnetic fields and other environmental stressors on the physiological responses and behavior of different species (RS-MESTD-Basic Research (BR or ON)-173027)
DOI: 10.1002/tox.22059
ISSN: 1520-4081; 1520-4081
PubMed: 25346405
WoS: 000372318300008
Scopus: 2-s2.0-84960472575
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/tox.22059https://radar.ibiss.bg.ac.rs/handle/123456789/3776