Uticaj fulerenola na aktivnost antioksidativnih enzima u ozračenoj kulturi ćelija humane eritroleukemije (K562)
The influence of fullerenol on antioxidative enzyme activity in irradiated human erythroleukemic cell line (K562)
2007
Authors:
Bogdanović, VišnjaStankov, Karmen
Nikolić, Aleksandra
Ičević, Ivana
Šolajić, Slavica
Bogdanović, Gordana
Đorđević, Aleksandar
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
Cell culture K562 samples were treated with fullerenol (C6o(OH)24) at a concentration of 10 nmol/mL and thereafter irradiated with X-rays (24Gy). The activity of gamma-glutamyltransfrease (γ-GT), total superoxide-dismutase (SOD) and glutathion-peroxidase (GSH-Px) was determined 1, 24 and 48 hours after irradiation. Irradiation induces an increase in the activity of all the investigated enzymes. Fullerenol in the applied dose decreased the γ-GT activity 24 and 48 h after irradiation. The total SOD activity is increased in both pretreated groups except in the irradiated group at the 48th hour. Treatment with fullerenol before irradiation increased GSH-Px activity in irradiated groups and decreased it in the control groups.