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Extremely Low Frequency Magnetic Field (50 Hz, 0.5 mT) Reduces Oxidative Stress in the Brain of Gerbils Submitted to Global Cerebral Ischemia
dc.creator | Rauš Balind, Snežana | |
dc.creator | Selaković, Vesna | |
dc.creator | Radenović, Lidija | |
dc.creator | Prolić, Zlatko | |
dc.creator | Petković, Branka | |
dc.date.accessioned | 2020-07-20T09:41:36Z | |
dc.date.available | 2020-07-20T09:41:36Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088921 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3788 | |
dc.description.abstract | Magnetic field as ecological factor has influence on all living beings. The aim of this study was to determine if extremely low frequency magnetic field (ELF-MF, 50 Hz, 0.5 mT) affects oxidative stress in the brain of gerbils submitted to 10-min global cerebral ischemia. After occlusion of both carotid arteries, 3-month-old gerbils were continuously exposed to ELF-MF for 7 days. Nitric oxide and superoxide anion production, superoxide dismutase activity and index of lipid peroxidation were examined in the forebrain cortex, striatum and hippocampus on the 7th (immediate effect of ELF-MF) and 14th day after reperfusion (delayed effect of ELF-MF). Ischemia per se increased oxidative stress in the brain on the 7th and 14th day after reperfusion. ELF-MF also increased oxidative stress, but to a greater extent than ischemia, only immediately after cessation of exposure. Ischemic gerbils exposed to ELF-MF had increased oxidative stress parameters on the 7th day after reperfusion, but to a lesser extent than ischemic or ELF-MF-exposed animals. On the 14th day after reperfusion, oxidative stress parameters in the brain of these gerbils were mostly at the control levels. Applied ELF-MF decreases oxidative stress induced by global cerebral ischemia and thereby reduces possible negative consequences which free radical species could have in the brain. The results presented here indicate a beneficial effect of ELF-MF (50 Hz, 0.5 mT) in the model of global cerebral ischemia. | en |
dc.language.iso | en | sr |
dc.publisher | Public Library of Science | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173027/RS// | sr |
dc.relation | MMA Grant (MFVMA/7/12-14) | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | PLoS One | sr |
dc.title | Extremely Low Frequency Magnetic Field (50 Hz, 0.5 mT) Reduces Oxidative Stress in the Brain of Gerbils Submitted to Global Cerebral Ischemia | en |
dc.type | article | sr |
dc.rights.license | BY | sr |
dcterms.abstract | Рауш Балинд, Снежана; Селаковић, Весна; Петковић, Бранка; Раденовић, Лидија; Пролић, Златко; | |
dc.rights.holder | © 2014 Rauš Balind et al. | sr |
dc.citation.issue | 2 | |
dc.citation.issue | 2 | |
dc.citation.volume | 9 | |
dc.identifier.doi | 10.1371/journal.pone.0088921 | |
dc.identifier.pmid | 24586442 | |
dc.identifier.scopus | 2-s2.0-84896788032 | |
dc.identifier.wos | 000331711900061 | |
dc.citation.spage | e88921 | |
dc.type.version | publishedVersion | sr |
dc.citation.rank | M21 |