dc.creator | Tovilović-Kovačević, Gordana | |
dc.creator | Krstić Milošević, Dijana | |
dc.creator | Ignjatović, Đurđica | |
dc.creator | Petković, Branka | |
dc.creator | Tomić, Mirko | |
dc.date.accessioned | 2020-07-22T08:50:37Z | |
dc.date.available | 2020-07-22T08:50:37Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1842-3582 | |
dc.identifier.uri | http://www.chalcogen.ro/index.php/journals/digest-journal-of-nanomaterials-and-biostructures/8-djnb/24-volume-6-number-3-july-september-2011 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3800 | |
dc.description.abstract | A diethylether extract of Gentiana kochiana aerial parts (GE), rich in two xanthones (gentiacaulein and gentiakochianin, 90% w/w), has already been shown to inhibit microsomal MAO enzymes in vitro and to exhibit certain antidepressant effects on mice. The aim of this study is to evaluate anxiolytic-like activity of GE in rodents by three behavioral tests, and to explore in vitro interactions of GE/xanthones with some anxiety-related elements of neurotransmission. The elevated plus maze test in rats and the staircase test in mice reveal specific anxiolytic-like influences of GE (5-20(40) mg/kg; ip), with the dose-effect ratios mainly converging to the inverted U-shaped curve. These effects are only partially analogous to the action of anxiolytic diazepam. In vitro assays demonstrate that neither GE nor the xanthones express substantial interactions with alpha(1)-adrenergic receptors, GABA(A) and GABA(B) receptors, and acetylcholine esterase. These results suggest a specific anxiolytic-like potential of GE in rodents and reduce the probability of particular neurochemical mechanisms to underlie this action. | en |
dc.language.iso | en | sr |
dc.publisher | National Institute of Material Physics, Romania | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41030/RS// | sr |
dc.rights | openAccess | sr |
dc.source | Digest Journal of Nanomaterials and Biostructures | sr |
dc.subject | Gentiana kochiana | sr |
dc.subject | Xanthones | sr |
dc.subject | Anxiolytic-like activity | sr |
dc.subject | Elevated plus maze test | sr |
dc.subject | Staircase test | sr |
dc.subject | Binding assays | sr |
dc.subject | Rodents | sr |
dc.title | Anxiolytic-like effects of xanthone-rich diethylether extract of Gentiana kochiana in rodents | en |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Товиловић-Ковачевић, Гордана; Крстић-Милошевић, Дијана; Томић, Мирко; Игњатовић, Ђурђица; Петковић, Бранка; | |
dc.rights.holder | © Virtual Company of Physics S.R.L. | sr |
dc.citation.issue | 3 | |
dc.citation.volume | 6 | |
dc.identifier.scopus | 2-s2.0-80053138958 | |
dc.identifier.wos | 000297986100058 | |
dc.citation.spage | 1385 | |
dc.citation.epage | 1392 | |
dc.type.version | publishedVersion | sr |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/6577/1395_Tovilovic.pdf | |
dc.citation.rank | M21 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_3800 | |