Time course of motor behavior changes in Mongolian gerbils submitted to different durations of cerebral ischemia
2006
Тип документа:
Чланак у часопису (Објављена верзија)
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© 2006 Elsevier B.V.
Метаподаци
Приказ свих података о документуАпстракт:
In addition to morphological changes, global cerebral ischemia leads to functional changes that can be assessed by behavioral examination. The purpose of this study was to investigate the impact of the duration of global cerebral ischemia on the time course of a comprehensive set of motor behaviors in Mongolian gerbils. The common carotid arteries of gerbils were occluded either for 5 min, 10 min, or 15 min. Gerbil motor behavior was recorded in the open field at 24 h, 48 h, 4 days, 7 days, 14 days, 21 days, and 28 days after reperfusion. Each session lasted for 60 min and was composed of six intervals of 10 min. Our results revealed that ischemic gerbils quickly develop locomotor and stereotypic hyperactivity, with the expected decrease of resting time. The most evident effect was observed in gerbils submitted to a 15 min ischemia, whose locomotor activity returned to nearly normal values after 7 days. In contrast, the duration of global cerebral ischemia had no effects on rearing, clockwise, or counter-clockwise rotation. These findings indicate that exposure to global cerebral ischernia induces changes in locomotion, stereotypy, and resting time. The magnitude and duration of these effects depend on the duration of ischernia.
Кључне речи:
Cerebral ischemia; Gerbils; Locomotion; Stereotypy; Rearing; Rotation; Open fieldИзвор:
Behavioural Brain Research, 2006, 175, 2, 362-373Финансирање / пројекти:
- Утицај магнетних поља као екофизиолошког фактора на различите биолошке системе и могућа примена у биомедицини (RS-143027)
- Military Medical Academy, Belgrade
DOI: 10.1016/j.bbr.2006.09.008
ISSN: 0166-4328
PubMed: 17067689
WoS: 000242680000019
Scopus: 2-s2.0-33750979871
URI
https://www.sciencedirect.com/science/article/pii/S0166432806005158?via%3Dihubhttps://radar.ibiss.bg.ac.rs/handle/123456789/3803