The effects of tiazofurin on basal and amphetamine-induced motor activity in rats
2004
Authors:
Petković, BrankaPešić, Vesna
Veskov, Rosica
Ristić, Slavica
Tasić, Jelena
Piperski, Vesna
Ruždijić, Sabera
Jokanović, Milan
Stukalov, Petar
Rakić, Ljubiša
Document Type:
Article (Published version)
,
© 2004 Elsevier Inc.
Metadata
Show full item recordAbstract:
The effects of tiazofurin (TR; 2-β-D-ribofuranosylthiazole-4-carboxamide), a purine nucleoside analogue on basal and amphetamine (AMPH)-induced locomotor and stereotypic activity of adult Wistar rat males were studied. The animals were injected with low (3.75, 7.5, and 15 mg/kg ip) and high (62.5, 125, and 250 mg/kg ip) TR doses. Neither low nor high TR doses influenced basal locomotor and stereotypic activity in comparison with the corresponding controls treated with saline only. However, pretreatment with TR at any dose applied, except for the lowest one, significantly decreased AMPH-induced (1.5 mg/kg ip) locomotor activity, while AMPH-induced stereotypic activity was inhibited with the two highest TR doses. In addition, TR was detected in the brain by HPLC already 15 min after the injection (125 mg/kg ip) to reach a maximum 2 h after the administration and was detectable in this tissue during the next 4 h. Our results indicate that TR modifies central regulation of the motor activity, possibly by influencing dopaminergic (DA-ergic) transmission.
Keywords:
Tiazofurin; Amphetamine; Motor activity; Open field; HPLC; Rat brainSource:
Pharmacology Biochemistry and Behavior, 2004, 77, 3, 575-582Funding / projects:
- Ministry of Science, Technology and Development of the Republic of Serbia (Contract #1641)
DOI: 10.1016/j.pbb.2003.12.025
ISSN: 0091-3057
PubMed: 15006469