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Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential
dc.creator | Tomić, Mirko | |
dc.creator | Kundaković, Marija | |
dc.creator | Butorović, Biljana | |
dc.creator | Petković, Branka | |
dc.creator | Andrić, Deana | |
dc.creator | Roglić, Goran | |
dc.creator | Ignjatović, Đurđica | |
dc.creator | Kostić-Rajačić, Slađana | |
dc.date.accessioned | 2020-07-24T08:23:12Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2004 | |
dc.identifier.issn | 0960-894X | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0960894X04007462?via%3Dihub | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3805 | |
dc.description.abstract | Six active compounds, among previously synthesized and screened arylpiperazines, were selected and evaluated for the binding affinity to rat dopamine, serotonin and alpha(1) receptors. Two compounds with benztriazole group had a 5-HT2A/D-2 binding ratio characteristic for atypical neuroleptics (>1, pK(i) values). Compound 2, 5-{2-[4-(2,3-dimethyl-phenyl)-piperazin-1-yl]ethyl}1H-benzotriazole, expressed clozapine-like in vitro binding profile at D-2, 5-HT2A and alpha1 receptors and a higher affinity for 5-HT1A receptors than clozapine. Also, it exhibited the noncataleptic behavioural pattern of atypical antipsychotics and antagonized d-amphetamine-induced hyperlocomotion in rats. | en |
dc.language.iso | en | sr |
dc.publisher | Pergamon-Elsevier Science Ltd | sr |
dc.relation | Ministry of Science, Technology and Development of the Republic of Serbia (Contract #1704) | sr |
dc.relation | Ministry of Science, Technology and Development of the Republic of Serbia (Contract #1698) | sr |
dc.rights | restrictedAccess | sr |
dc.source | Bioorganic and Medicinal Chemistry Letters | sr |
dc.subject | Arylpiperazine | sr |
dc.subject | Dopamine receptors | sr |
dc.subject | Serotonin receptors | sr |
dc.subject | Atypical antipsychotic | sr |
dc.title | Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential | en |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Роглић, Горан; Игњатовић, Ђурђица; Костић-Рајачић, Слађана; Aндрић, Деана; Петковић, Бранка; Буторовић, Биљана; Кундаковић, Марија; Томић, Мирко; | |
dc.rights.holder | © 2004 Elsevier Ltd. | sr |
dc.citation.issue | 16 | |
dc.citation.volume | 14 | |
dc.identifier.doi | 10.1016/j.bmcl.2004.06.005 | |
dc.identifier.pmid | 15261283 | |
dc.identifier.scopus | 2-s2.0-3142691095 | |
dc.identifier.wos | 000222923300029 | |
dc.citation.spage | 4263 | |
dc.citation.epage | 4266 | |
dc.type.version | publishedVersion | sr |
dc.citation.rank | M21 |