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Biological Potential of Halfsandwich Ruthenium(II) and Iridium (III) Complexes
dc.creator | Ludwig, Gerd | |
dc.creator | Mojić, Marija | |
dc.creator | Bulatović, Mirna | |
dc.creator | Mijatović, Sanja | |
dc.creator | Maksimović-Ivanić, Danijela | |
dc.creator | Steinborn, Dirk | |
dc.creator | Kaluđerović, Goran N | |
dc.date.accessioned | 2020-07-31T08:40:04Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1871-5206 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3827 | |
dc.description.abstract | In vitro studies with the ruthenium(II) and analogous iridium(III) complexes [Ru(η6- p-cymene)Cl2{Ph2PCH2CH2CH2S(O)xPh-κP}], [Ru(η6-p-cymene)Cl{Ph2PCH2CH2CH2S(O)xPh- κP,κS}][PF6] (1-4), [Ir(η5-C5Me5)Cl2{Ph2PCH2CH2CH2S(O)xPh-κP}] and [Ir(η5-C5Me5)Cl{Ph2 PCH2CH2CH2S(O)xPh-κP,κS}][PF6] (5-8; x = 0, 1) revealed the high selectivity toward the 8505C, A253, MCF-7, SW480 and 518A2 cancer cell lines. Thus, the cationic ruthenium complex 4 proved to be the most selective one. In case of the neutral and cationic ruthenium complexes 1-4 the caspase-dependent apoptotic cell death was proven as the main cause of the drug's tumoricidal action on 8505C cell line. | en |
dc.language.iso | en | sr |
dc.publisher | Sharjah: Bentham Science Publishers | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Anti-Cancer Agents in Medicinal Chemistry | sr |
dc.subject | Apoptosis | sr |
dc.subject | Autophagy | sr |
dc.subject | Caspase | sr |
dc.subject | Cisplatin | sr |
dc.subject | Iridium(III) complexes | sr |
dc.subject | Ruthenium(II) complexes | sr |
dc.title | Biological Potential of Halfsandwich Ruthenium(II) and Iridium (III) Complexes | en |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Стеинборн, Дирк; Калуђеровић, Горан Н; Лудwиг, Герд; Мојић, Марија; Булатовић, Мирна; Мијатовић, Сања; Максимовић-Иванић, Данијела; | |
dc.rights.holder | © 2016 Bentham Science Publishers | sr |
dc.citation.issue | 11 | |
dc.citation.volume | 16 | |
dc.identifier.doi | 10.2174/1871520615666151029100749 | |
dc.identifier.pmid | 26510901 | |
dc.identifier.scopus | 2-s2.0-84992360776 | |
dc.identifier.wos | 000390325500008 | |
dc.citation.spage | 1455 | |
dc.citation.epage | 1460 | |
dc.type.version | publishedVersion | sr |
dc.citation.rank | M22 |