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Extracts Characterization and In Vitro Evaluation of Potential Immunomodulatory Activities of the Moss Hypnum cupressiforme Hedw.
dc.creator | Lunić, Tanja M. | |
dc.creator | Oalđe, Mariana M. | |
dc.creator | Mandić, Marija R. | |
dc.creator | Sabovljević, Aneta D | |
dc.creator | Sabovljević, Marko S. | |
dc.creator | Gašić, Uroš | |
dc.creator | Duletić-Laušević, Sonja N. | |
dc.creator | Božić, Bojan Dj. | |
dc.creator | Božić Nedeljković, Biljana Dj. | |
dc.date.accessioned | 2020-09-03T11:51:15Z | |
dc.date.available | 2020-09-03T11:51:15Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1420-3049 | |
dc.identifier.uri | https://www.mdpi.com/1420-3049/25/15/3343 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/32717985 | |
dc.identifier.uri | http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC7436104 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/123456789/3851 | |
dc.description.abstract | Recently, there has been an increasing interest in the chemistry and biological potential of mosses, since a large number of biologically active compounds have been found within these species. This study aimed at examining the chemical composition and immunomodulatory potential (antioxidant, antidiabetic, anti-neuroinflammatory/antineurodegenerative, and antitumor activities) of moss Hypnum cupressiforme Hedw. extracts. Corresponding extracts have been obtained applying Soxhlet extractor. The chemical characterization was performed using spectrophotometric assays and liquid chromatography-mass spectrometry (LC-MS). The extracts were analyzed for antioxidant activity and for inhibitory activities on α-glucosidase, α-amylase, acetylcholinesterase, and tyrosinase. Additionally, extracts were tested against four cell lines-MRC-5, BV2, HCT-116, and MDA-MB-231-for antitumor and anti-inflammatory activities. Chemical analysis of extracts revealed the presence of flavonoids, phenolic acids, and triterpenoids. Major compounds identified by LC-MS in H. cupressiforme were kaempferol and five phenolic acids: p-hydroxybenzoic, protocatechuic, p-coumaric, gallic, and caffeic acid. According to biochemical assays the investigated extracts exhibited significant immunomodulatory potential. Significant antiproliferative potential against MDA-MB-231 cells has been observed together with the promising anti-neuroinflammatory application. The obtained data suggest that moss H. cupressiforme is a valuable natural source of biologically active compounds with potential application in the pharmaceutical industry. | en |
dc.publisher | MDPI AG | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200178/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Molecules (Basel, Switzerland) | |
dc.subject | Hypnum cupressiforme | |
dc.subject | Anti-neuroinflammatory/antineurodegenerative | |
dc.subject | Antidiabetic | |
dc.subject | Antioxidant | |
dc.subject | Antitumor activity | |
dc.subject | Moss extract | |
dc.title | Extracts Characterization and In Vitro Evaluation of Potential Immunomodulatory Activities of the Moss Hypnum cupressiforme Hedw. | en |
dc.type | article | en |
dc.rights.license | BY | |
dcterms.abstract | Дулетић-Лаушевић, Соња Н.; Гашић, Урош; Сабовљевић, Марко С.; Лунић, Тања М.; Оалђе, Мариана М.; Мандић, Марија Р.; Сабовљевић, Aнета Д; Божић, Бојан Дј.; Божић Недељковић, Биљана Дј.; | |
dc.rights.holder | © 2020 by the authors. | |
dc.citation.issue | 15 | |
dc.citation.volume | 25 | |
dc.identifier.doi | 10.3390/molecules25153343 | |
dc.identifier.pmid | 32717985 | |
dc.identifier.scopus | 2-s2.0-85088810618 | |
dc.identifier.wos | 000567095900001 | |
dc.citation.apa | Lunić, T. M., Oalđe, M. M., Mandić, M. R., Sabovljević, A. D., Sabovljević, M. S., Gašić, U. M., et al. (2020). Extracts Characterization and In Vitro Evaluation of Potential Immunomodulatory Activities of the Moss Hypnum cupressiforme Hedw. Molecules (Basel, Switzerland), 25(15), 3343. | |
dc.citation.vancouver | Lunić TM, Oalđe MM, Mandić MR, Sabovljević AD, Sabovljević MS, Gašić UM, Duletić-Laušević SN, Božić BD, Božić Nedeljković BD. Extracts Characterization and In Vitro Evaluation of Potential Immunomodulatory Activities of the Moss Hypnum cupressiforme Hedw. Molecules. 2020;25(15):3343. | |
dc.citation.spage | 3343 | |
dc.type.version | publishedVersion | |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/7205/molecules-25-03343.pdf | |
dc.citation.rank | M22 |