First Extensive Polyphenolic Profile of Erodium cicutarium with Novel Insights to Elemental Composition and Antioxidant Activity.
2020
Authors:
Ljoljić Bilić, VanjaGašić, Uroš
Milojković-Opsenica, Dušanka
Nemet, Ivan
Rončević, Sanda
Kosalec, Ivan
Vuković Rodriguez, Jadranka
Document Type:
Article (Accepted Version)
,
© 2020 Wiley-VHCA AG, Zurich, Switzerland
Metadata
Show full item recordAbstract:
Erodium cicutarium is known for its total polyphenolic content, but this work reveals the first highly detailed profile of E. cicutarium, obtained with UHPLC-LTQ OrbiTrap MS4 and UHPLC-QqQ-MS/MS techniques. A total of 85 phenolic compounds were identified and 17 constituents were quantified. Overall, 25 new compounds were found, which have not yet been reported for the Erodium genera, or the family Geraniaceae. Along with methanolic extracts, the so far poorly investigated water extracts exhibited in vitro antioxidant activity according to all performed assays, including the ferric reducing/antioxidant power assay (FRAP), 2,2-diphenyl-1-picrylhydrazyl assay (DPPH), 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) assay (ABTS) and cupric ion reducing antioxidant capacity assay (CUPRAC). Elemental composition analysis performed with inductively coupled plasma atomic emission spectrometry (ICP-AES) and, additionally, hydride generation atomic absorption spectrometry (HydrEA-ETAAS) showed six most abundant elements to be decreasing as follows: Mg>Ca>K>S>P>Na, and gave first data regarding inorganic arsenic content (109.3-248.4 ng g-1 ). These results suggest E. cicutarium to be a valuable source of various phenolic compounds with substantial potential for further bioactivity testing.
Keywords:
Erodium cicutarium; Geraniaceae; Antioxidant activity; Inorganic arsenic species; Polyphenolic profilingSource:
Chemistry & Biodiversity, 2020, 80, cbdv.202000280-Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200168 (University of Belgrade, Faculty of Chemistry) (RS-MESTD-inst-2020-200168)
- University of Zagreb, Croatia
DOI: 10.1002/cbdv.202000280
ISSN: 1612-1872
PubMed: 32634273
WoS: 000561077400001
Scopus: 2-s2.0-85089695653
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/cbdv.202000280http://www.ncbi.nlm.nih.gov/pubmed/2634273
http://www.ncbi.nlm.nih.gov/pubmed/32634273
https://radar.ibiss.bg.ac.rs/123456789/3855