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Chemo-protective and regenerative effects of diarylheptanoids from the bark of black alder (Alnus glutinosa) in human normal keratinocytes
dc.creator | Dinić, Jelena | |
dc.creator | Ranđelović, Teodora | |
dc.creator | Stanković, Tijana | |
dc.creator | Dragoj, Miodrag | |
dc.creator | Isaković, Aleksandra | |
dc.creator | Novaković, Miroslav | |
dc.creator | Pešić, Milica | |
dc.date.accessioned | 2020-09-14T10:59:45Z | |
dc.date.available | 2016-07-07 | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0367-326X | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0367326X1530040X | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/123456789/3864 | |
dc.description.abstract | Medicinal plants are recognized from ancient times as a source of diverse therapeutic agents and many of them are used as dietary supplements. Comprehensive approaches are needed that would identify bioactive components with evident activity against specific indications and provide a better link between science (ethno-botany, chemistry, biology and pharmacology) and market. Recently, the bark of black alder (Alnus glutinosa) appeared at market in the form of food supplement for treatment of different skin conditions. This study aimed to evaluate protective effects of two diarylheptanoids isolated from the bark of black alder: platyphylloside, 5(S)-1,7-di(4-hydroxyphenyl)-3-heptanone-5-O-β-D-glucopyranoside (1) and its newly discovered analog 5(S)-1,7-di(4-hydroxyphenyl)-5-O-β-D-[6-(E-p-coumaroylglucopyranosyl)]heptane-3-one (2) towards doxorubicin damaging activity. To that end, we employed HaCaT cells, non-cancerous human keratinocytes commonly used for skin regenerative studies. Diarylheptanoids significantly antagonized the effects of doxorubicin by lowering the sensitivity of HaCaT cells to this drug. Compound 2 prevented doxorubicin-induced cell death by activating autophagy. Both 1 and 2 protected HaCaT cells against doxorubicin-induced DNA damage. They significantly promoted migration and affected F-actin distribution. These results indicate that chemo-protective effects of diarylheptanoids may occur at multiple subcellular levels. Therefore, diarylheptanoids 1 and 2 could be considered as protective agents for non-cancerous dividing cells during chemotherapy. | en |
dc.language.iso | en | sr |
dc.publisher | Elsevier | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41031/RS// | sr |
dc.rights | embargoedAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Fitoterapia | sr |
dc.subject | Diarylheptanoid | sr |
dc.subject | Curcumin | sr |
dc.subject | Doxorubicin | sr |
dc.subject | DNA damage | sr |
dc.subject | Cell motility | sr |
dc.subject | Chemoprotection | sr |
dc.title | Chemo-protective and regenerative effects of diarylheptanoids from the bark of black alder (Alnus glutinosa) in human normal keratinocytes | en |
dc.type | article | sr |
dc.rights.license | BY-NC-ND | sr |
dcterms.abstract | Исаковић, Aлександра; Новаковић, Мирослав; Ранђеловић, Теодора; Динић, Јелена; Пешић, Милица; Станковић, Тијана; Драгој, Миодраг; | |
dc.rights.holder | © 2015 Elsevier Inc. | sr |
dc.citation.volume | 105 | |
dc.description.note | This is the peer reviewed version of the following article: Dinić J, Ranđelović T, Stanković T, Dragoj M, Isaković A, Novaković M, Pešić M. Chemo-protective and regenerative effects of diarylheptanoids from the bark of black alder (Alnus glutinosa) in human normal keratinocytes. Fitoterapia. 2015;105:169–76. [https://doi.org/10.1016/j.fitote.2015.07.003] | |
dc.description.note | Related to: [https://radar.ibiss.bg.ac.rs/123456789/3865]. | |
dc.identifier.doi | 10.1016/j.fitote.2015.07.003 | |
dc.identifier.pmid | 26162555 | |
dc.identifier.scopus | 2-s2.0-84937539499 | |
dc.identifier.wos | 000361401500027 | |
dc.citation.vancouver | Dinić J, Ranđelović T, Stanković T, Dragoj M, Isaković A, Novaković M, Pešić M. Chemo-protective and regenerative effects of diarylheptanoids from the bark of black alder (Alnus glutinosa) in human normal keratinocytes. Fitoterapia. 2015;105:169–76. | |
dc.citation.spage | 169 | |
dc.citation.epage | 176 | |
dc.type.version | acceptedVersion | sr |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/7240/10.1016j.fitote.2015.07.003.pdf | |
dc.citation.rank | M22 |