Alkylamino and aralkylamino derivatives of avarone and its mimetic as selective agents against non-small cell lung cancer cells, their antibacterial and antifungal potential
2018
Аутори:
Jeremić, MarkoDinić, Jelena
Pešić, Milica
Nešović, Marija
Novaković, Irena
Šegan, Dejan
Sladić, Dušan
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
In this paper, the synthesis of fourteen alkylamino and arylamino derivatives of sesquiterpene quinone avarone and its model compound tert-butylquinone is described. Branched, cyclic, allylic and benzylic alkylamino/arylamino groups were introduced into the quinone moiety. For all the obtained derivatives, their biological activity and redox properties were studied. The cytotoxic activity of the synthesized derivatives towards multidrug resistant (MDR) human non-small cell lung carcinoma NCI-H460/R cells, their sensitive counterpart NCI-H460 and human normal keratinocytes (HaCaT) was investigated. The antimicrobial activity towards Gram-positive and Gram-negative bacteria, and fungal cultures was determined. Some of the synthesized derivatives showed selectivity for cancer cells, including MDR cells. Regarding their cell death induction potential, the most promising compounds were allylamino derivatives, preferentially triggering apoptosis, with high selectivity for cancer cells, including MDR cells. Several compounds showed promising antimicrobial activity, comparable to those of commercial antibiotic and antimycotic agents.
Кључне речи:
Quinones; Anticancer activity; Multidrug resistant; Apoptosis; Antimicrobial activity; Cyclic voltammetryИзвор:
Journal of the Serbian Chemical Society, 2018, 83, 11, 1193-1207Финансирање / пројекти:
- Идентификација молекуларних маркера за предикцију прогресије тумора, одговора на терапију и исхода болести (RS-41031)
- Интеракције природних производа, њихових деривата и комплексних једињења са протеинима и нуклеинским киселинама (RS-172055)
DOI: 10.2298/JSC180627062J
ISSN: 0352-5139
WoS: 000452167500001
Scopus: 2-s2.0-85053920097
URI
http://www.doiserbia.nb.rs/Article.aspx?ID=0352-51391800062Jhttps://radar.ibiss.bg.ac.rs/123456789/3866