Effects of antipsychotic drug administration on antioxidative defense enzymes in male rat kidney
2016
Authors:
Nikolić-Kokić, AleksandraMijušković, Ana
Tatalović, Nikola
Brkljačić, Jelena
Miler, Marko
Oreščanin Dušić, Zorana
Nikolić, Milan
Milošević, Verica
Blagojević, Duško
Spasić, Mihajlo
Miljević, Čedo
Document Type:
Article (Published version)
,
© 2016 Taylor & Francis.
Metadata
Show full item recordAbstract:
The use of atypical antipsychotic drugs (APD) was reported to be associated with adverse effects
on the kidneys. Thus, the aim of this study was to examine whether APD exerted their adverse
effects by interfering with the renal antioxidant defense system. Male 3-mo-old Wistar rats were
treated for 28 d with ziprasidone (ZIP), clozapine (CLO), or sertindole (SER) using a daily dose
recommended for antipsychotic drug therapy. The expression and activities of antioxidant
enzymes superoxide dismutase (SOD) type 1 and type 2, catalase (CAT), glutathione reductase
(GR), and glutathione S-transferases (GSTs) activity were measured in the kidneys. Changes in the
kidneys were also evaluated histologically. Ziprasidone, CLO, and SER reduced renal SOD type 1
and type 2 activities. Decreased CAT activity was observed only in SER-treated rats. An inhibition
in GR activity and increased activity of GST was found only after treatment with CLO. Histological
analysis showed dilatation of proximal tubules in kidneys with all three drugs. In conclusion, data
indicate that redox disturbances may contribute to renal morphologic alterations in proximal
tubules in rats treated with all APD.
Note:
Keywords:
ziprasidone; clozapine; sertindole; proximal tubules dilatationSource:
Journal of Toxicology and Environmental Health, Part A: Current Issues, 2016, 79, 20, 905-911Funding / projects:
- Molecular mechanisms of redox signalling in homeostasis: adaptation and pathology (RS-MESTD-Basic Research (BR or ON)-173014)
DOI: 10.1080/15287394.2016.1201706
ISSN: 1528-7394
PubMed: 27644343