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Protein kinases as targets for developing anticancer agents from marine organisms.
dc.creator | Qiao, Gan | |
dc.creator | Bi, Kangping | |
dc.creator | Liu, Junhong | |
dc.creator | Cao, Shousong | |
dc.creator | Liu, Minghua | |
dc.creator | Pešić, Milica | |
dc.creator | Lin, Xiukun | |
dc.date.accessioned | 2020-10-27T11:18:56Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0304-4165 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/33038451 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3929 | |
dc.description.abstract | Protein kinases play a fundamental role in the intracellular transduction because of their ability to phosphorylate plethora of proteins. Over the past three decades, numerous protein kinase inhibitors have been identified and are being used clinically successfully. The biodiversity of marine organisms provides a rich source for the discovery and development of novel anticancer agents in the treatment of human malignancies and a lot of bioactive ingredients from marine organisms display anticancer effects by affecting the protein kinases-mediated pathways. In the present mini-review, anticancer compounds from marine source were reviewed and discussed in context of their targeted pathways associated with protein kinases and the progress of these compounds as anticancer agents in recent five years were emphasized. The molecular entities and their modes of actions were presented. We focused on protein kinases-mediated signaling pathways including PI3K/Akt/mTOR, p38 MAPK, and EGFR. The marine compounds targeting special pathways of protein kinases were highlighted. We have also discussed the existing challenges and prospects related to design and development of novel protein kinase inhibitors from marine sources. | en |
dc.publisher | Elsevier B.V. | |
dc.relation | National Science Foundation of China (#81573457, #81773776) | |
dc.relation | Taishan Talents project of Shandong Province | |
dc.relation | Department of Science and Technology in Shandong Province of China | |
dc.relation | Department of Science and Technology in Sichuan of China | |
dc.relation | International Collaborative Project of the MOST of China | |
dc.rights | restrictedAccess | |
dc.source | Biochimica et Biophysica Acta - General Subjects | |
dc.subject | Anticancer activity | |
dc.subject | EGFR | |
dc.subject | Marine organisms | |
dc.subject | P13K/Akt/mTOR | |
dc.subject | Protein kinase inhibitors | |
dc.subject | p38 MAPK | |
dc.title | Protein kinases as targets for developing anticancer agents from marine organisms. | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Цао, Схоусонг; Пешић, Милица; Qиао, Ган; Би, Кангпинг; Лиу, Јунхонг; Лиу, Мингхуа; Лин, Xиукун; Протеин кинасес ас таргетс фор девелопинг антицанцер агентс фром марине органисмс.; | |
dc.rights.holder | © 2020 Elsevier B.V. | |
dc.citation.issue | 1 | |
dc.citation.volume | 1865 | |
dc.identifier.doi | 10.1016/j.bbagen.2020.129759 | |
dc.identifier.pmid | 33038451 | |
dc.identifier.scopus | 2-s2.0-85092485513 | |
dc.identifier.wos | 000594131800022 | |
dc.citation.apa | Qiao, G., Bi, K., Liu, J., Cao, S., Liu, M., Pešić, M., et al. (2021). Protein kinases as targets for developing anticancer agents from marine organisms. Biochimica et Biophysica Acta - General Subjects, 1865(1), 129759. | |
dc.citation.vancouver | Qiao G, Bi K, Liu J, Cao S, Liu M, Pešić M, Lin X. Protein kinases as targets for developing anticancer agents from marine organisms. Biochim Biophys Acta - Gen Subj. 2021;1865(1):129759. | |
dc.citation.spage | 129759 | |
dc.type.version | publishedVersion | |
dc.citation.rank | M21 |