Hypertension in Polycystic Ovary Syndrome: Novel Insights.
2020
Аутори:
Macut, ĐuroMladenović, Violeta
Bjekić-Macut, Jelica
Livadas, Sarantis
Stanojlović, Olivera
Hrnčić, Dragan
Rašić-Marković, Aleksandra
Vojnović-Milutinović, Danijela
Andrić, Zoran
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2020 Bentham Science Publishers
Метаподаци
Приказ свих података о документуАпстракт:
Polycystic ovary syndrome (PCOS) is a common endocrine disease in women during reproductive age. It was shown that PCOS women are with high risk for dyslipidemia, glucose intolerance, type 2 diabetes and metabolic syndrome. These factors are considered to represent traditional risk factors for the occurrence of cardiovascular disease. Observed increased risk for hypertension in PCOS women seems to be associated with insulin resistance and hyperinsulinemia. Both conditions interfere with the endothelium-dependent vasodilatation mechanisms causing vascular muscle wall hypertrophy. Obesity and insulin resistance are considered key factors for the alteration of blood pressure in PCOS women. Higher cardiovascular risk is implicated in PCOS with aging and its consequent association with both systolic and diastolic blood pressure. The elements of renin-angiotensin-aldosterone system (RAAS) have an impact on endothelial dysfunction as a marker of cardiovascular damage that could be modified is women with PCOS. Androgens and components of RAAS are involved in the process of atherogenesis in PCOS women. Therefore, it is hypothesized that spironolactone treatment could ameliorate endothelial dysfunction in PCOS women. Recently it was shown that telmisartan, angiotensin II receptor antagonist poses insulinsensitizing capacity to activate PPAR gamma and mediate favorable metabolic and reproductive effects in hypertensive PCOS women.
Кључне речи:
Polycystic ovary syndrome; RAAS; Hyperinsulinemia; Hypertension; Insulin resistance; ObesityИзвор:
Current Hypertension Reviews, 2020, 16, 1, 55-60Финансирање / пројекти:
- Развој анималних модела епилепсије и тестирање конвулзивних и антиконвулзивних супстанци (RS-MESTD-Basic Research (BR or ON)-175032)
- Улога стероидних хормона у неуроендокриној адаптацији на стрес и патофизиологији метаболичког синдрома - молекуларни механизми и клиничке импликације (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41009)
DOI: 10.2174/1573402115666190531071422
ISSN: 1573-4021
PubMed: 31146668
WoS: 000514550200009
Scopus: 2-s2.0-85077025533
URI
http://www.eurekaselect.com/172346/articlehttp://www.ncbi.nlm.nih.gov/pubmed/31146668
https://radar.ibiss.bg.ac.rs/handle/123456789/3969