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Hypertension in Polycystic Ovary Syndrome: Novel Insights.
dc.creator | Macut, Đuro | |
dc.creator | Mladenović, Violeta | |
dc.creator | Bjekić-Macut, Jelica | |
dc.creator | Livadas, Sarantis | |
dc.creator | Stanojlović, Olivera | |
dc.creator | Hrnčić, Dragan | |
dc.creator | Rašić-Marković, Aleksandra | |
dc.creator | Vojnović-Milutinović, Danijela | |
dc.creator | Andrić, Zoran | |
dc.date.accessioned | 2020-11-09T09:08:46Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1573-4021 | |
dc.identifier.uri | http://www.eurekaselect.com/172346/article | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/31146668 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3969 | |
dc.description.abstract | Polycystic ovary syndrome (PCOS) is a common endocrine disease in women during reproductive age. It was shown that PCOS women are with high risk for dyslipidemia, glucose intolerance, type 2 diabetes and metabolic syndrome. These factors are considered to represent traditional risk factors for the occurrence of cardiovascular disease. Observed increased risk for hypertension in PCOS women seems to be associated with insulin resistance and hyperinsulinemia. Both conditions interfere with the endothelium-dependent vasodilatation mechanisms causing vascular muscle wall hypertrophy. Obesity and insulin resistance are considered key factors for the alteration of blood pressure in PCOS women. Higher cardiovascular risk is implicated in PCOS with aging and its consequent association with both systolic and diastolic blood pressure. The elements of renin-angiotensin-aldosterone system (RAAS) have an impact on endothelial dysfunction as a marker of cardiovascular damage that could be modified is women with PCOS. Androgens and components of RAAS are involved in the process of atherogenesis in PCOS women. Therefore, it is hypothesized that spironolactone treatment could ameliorate endothelial dysfunction in PCOS women. Recently it was shown that telmisartan, angiotensin II receptor antagonist poses insulinsensitizing capacity to activate PPAR gamma and mediate favorable metabolic and reproductive effects in hypertensive PCOS women. | en |
dc.publisher | Bentham Science Publishers Ltd. | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175032/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41009/RS// | |
dc.rights | restrictedAccess | |
dc.source | Current Hypertension Reviews | |
dc.subject | Polycystic ovary syndrome | |
dc.subject | RAAS | |
dc.subject | Hyperinsulinemia | |
dc.subject | Hypertension | |
dc.subject | Insulin resistance | |
dc.subject | Obesity | |
dc.title | Hypertension in Polycystic Ovary Syndrome: Novel Insights. | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Станојловић, Оливера; Рашић-Марковић, Aлександра; Aндрић, Зоран; Војновић Милутиновић, Данијела; Хрнчић, Драган; Мацут, Ђуро; Младеновић, Виолета; Бјекић-Мацут, Јелица; Ливадас, Сарантис; | |
dc.rights.holder | © 2020 Bentham Science Publishers | |
dc.citation.issue | 1 | |
dc.citation.volume | 16 | |
dc.identifier.doi | 10.2174/1573402115666190531071422 | |
dc.identifier.pmid | 31146668 | |
dc.identifier.scopus | 2-s2.0-85077025533 | |
dc.identifier.wos | 000514550200009 | |
dc.citation.apa | Macut, D., Mladenović, V., Bjekić-Macut, J., Livadas, S., Stanojlović, O., Hrnčić, D., et al. (2020). Hypertension in Polycystic Ovary Syndrome: Novel Insights. Current Hypertension Reviews, 16(1), 55–60. | |
dc.citation.vancouver | Macut D, Mladenović V, Bjekić-Macut J, Livadas S, Stanojlović O, Hrnčić D, Rašić-Marković A, Milutinović DV, Andrić Z. Hypertension in Polycystic Ovary Syndrome: Novel Insights. Curr Hypertens Rev. 2020 Feb 13;16(1):55–60. | |
dc.citation.spage | 55 | |
dc.citation.epage | 60 | |
dc.type.version | publishedVersion |