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Fructose Consumption Affects Glucocorticoid Signaling in the Liver of Young Female Rats
dc.creator | Elaković, Ivana | |
dc.creator | Kovačević, Sanja | |
dc.creator | Vojnović-Milutinović, Danijela | |
dc.creator | Nikolić-Kokić, Aleksandra | |
dc.creator | Glban, Alhadi M. | |
dc.creator | Spasić, Mihajlo | |
dc.creator | Tappy, Luc | |
dc.creator | Đorđević, Ana | |
dc.creator | Matić, Gordana | |
dc.creator | Brkljačić, Jelena | |
dc.date.accessioned | 2020-11-13T12:36:11Z | |
dc.date.available | 2020-11-13T12:36:11Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2072-6643 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3983 | |
dc.description.abstract | The effects of early-life fructose consumption on hepatic signaling pathways and their relation to the development of metabolic disorders in later life are not fully understood. To investigate whether fructose over consumption at a young age induces alterations in glucocorticoid signaling that might contribute to development of metabolic disturbances, we analysed glucocorticoid receptor hormone-binding parameters and expression of its target genes involved in gluconeogenesis (phosphoenolpyruvate carboxykinase and glucose-6-phosphatase) and lipid metabolism (lipin-1),as well as redox and inflammatory status in the liver of female rats subjected to a fructose-rich diet immediately after weaning. The fructose diet increased hepatic corticosterone concentration,11β-hydroxysteroid dehydrogenase type 1 level, glucocorticoid receptor protein level and hormone-binding activity, as well as lipin-1 level. The expression of glucose-6-phosphatase was reduced in fructose-fed rats, while phosphoenolpyruvate carboxykinase remained unaltered.The fructose-rich diet increased the level of fructose transporter GLUT2, while the expression of fructolytic enzymes fructokinase and aldolase B remained unaltered. The diet also affected pro-inflammatory pathways, but had no effect on the antioxidant defence system. In conclusion, a fructose-rich diet applied immediately after weaning promoted lipogenesis and enhanced hepatic glucocorticoid signaling, possibly to protect against inflammatory damage, but without an effect on gluconeogenesis and antioxidant enzymes. Yet, prolonged treatment might ultimately lead to more pronounced metabolic disturbances. | en |
dc.language.iso | en | sr |
dc.publisher | Basel, Switzerland : Multidisciplinary Digital Publishing Institute (MDPI) | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41009/RS// | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Nutrients | sr |
dc.subject | glucocorticoid receptor | sr |
dc.subject | inflammation | sr |
dc.subject | antioxidant enzymes | sr |
dc.subject | lipogenesis | sr |
dc.subject | fructose-fed rat | sr |
dc.subject | lipin-1 | sr |
dc.title | Fructose Consumption Affects Glucocorticoid Signaling in the Liver of Young Female Rats | en |
dc.type | article | sr |
dc.rights.license | BY | sr |
dcterms.abstract | Бркљачић, Јелена; Елаковић, Ивана; Ковачевић, Сања; Војновић Милутиновић, Данијела; Николић-Кокић, Aлександра; Глбан, Aлхади М.; Спасић, Михајло; Таппy, Луц; Ђорђевић, Aна; Матић, Гордана; | |
dc.rights.holder | © 2020 by the authors | sr |
dc.citation.issue | 11 | |
dc.citation.volume | 12 | |
dc.identifier.doi | 10.3390/nu12113470 | |
dc.identifier.scopus | 2-s2.0-85096276677 | |
dc.identifier.wos | 000593779000001 | |
dc.citation.apa | Elaković, I., Kovačević, S., Vojnović Milutinović, D., Nikolić-Kokić, A., Glban, A. M., Spasić, M., et al. (2020). Fructose Consumption Affects Glucocorticoid Signaling in the Liver of Young Female Rats. Nutrients, 12(11), 3470. | |
dc.citation.vancouver | Elaković I, Kovačević S, Vojnović Milutinović D, Nikolić-Kokić A, Glban AM, Spasić M, Tappy L, Djordjevic A, Matić G, Brkljačić J. Fructose Consumption Affects Glucocorticoid Signaling in the Liver of Young Female Rats. Nutrients. 2020;12(11):3470. | |
dc.citation.spage | 3470 | |
dc.type.version | publishedVersion | sr |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/7666/bitstream_7666.pdf | |
dc.citation.rank | M21 |